Evidence map›Paper›PMID 32461055›Full record

ArticleHematology, transfusion and cell therapy

Polymorphisms in the heme oxygenase-1 and bone morphogenetic protein receptor type 1b genes and estimated glomerular filtration rate in Brazilian sickle cell anemia patients.

Okeke Chinedu, Wouitchékpo Vincent Tonassé, Dulcinéia Martins Albuquerque, Igor de Farias Domingos, Aderson da Silva Araújo, Marcos André Cavalcanti Bezerra, Maria de Fátima Sonati, Magnun Nueldo Nunes Dos Santos

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hematology, transfusion and cell therapy. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 3 pooled it
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 3 syntheses or guidelines pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Review
  5. Article
  6. Article
  7. Sickle Cell Disease and CKD: An Update.American journal of nephrology · 2024
    Review
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Okeke ChineduFaculdade de Ciências Médicas, Universidade Estadual de Campinas (FCM/UNICAMP), Campinas, SP, Brazil.
Wouitchékpo Vincent TonasséFaculdade de Ciências Médicas, Universidade Estadual de Campinas (FCM/UNICAMP), Campinas, SP, Brazil.
Dulcinéia Martins AlbuquerqueCentro de Hematologia e Hemoterapia, Universidade Estadual de Campinas (Hemocentro/UNICAMP), Campinas, SP, Brazil.
Igor de Farias DomingosPrograma de Pós-graduação em Genética, Universidade Federal de Pernambuco (UFPE), Recife, PE, Brazil.
Aderson da Silva AraújoFundação de Hematologia e Hemoterapia de Pernambuco (HEMOPE), Recife, SP, Brazil.
Marcos André Cavalcanti BezerraPrograma de Pós-graduação em Genética, Universidade Federal de Pernambuco (UFPE), Recife, PE, Brazil.
Maria de Fátima SonatiFaculdade de Ciências Médicas, Universidade Estadual de Campinas (FCM/UNICAMP), Campinas, SP, Brazil.
Magnun Nueldo Nunes Dos SantosFaculdade de Ciências Médicas, Universidade Estadual de Campinas (FCM/UNICAMP), Campinas, SP, Brazil. Electronic address: santosmn@unicamp.br.
Universidade Estadual de Campinas (UNICAMP) · BRUniversidade Federal de Pernambuco · BRFundação Hemopa · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionMutations affecting genes involved in oxidative and signaling pathways may be associated with kidney disease in sickle cell anemia. We determined the allele and genotype frequencies of some polymorphisms in the promoter regions of the Heme Oxygenase-1 (HMOX1) [rs2071746 (A>T) and (GT)n repeats, short (S) and long (L) alleles] and Bone Morphogenetic Protein Receptor type-1B (BMPR1B) [rs17022863 (A>G), rs4331783 (A>G) and rs1470409 (A>G)] genes in 75 adult patients with sickle cell anemia and 160 healthy controls and investigated whether these polymorphisms may influence the estimated glomerular filtration rate for the patients.

methodsThe single nucleotide polymorphisms were genotyped using the TaqMan assays, the HMOX1(GT)n repeats were determined by polymerase chain reaction fragment size analysis and the estimated glomerular filtration rate was calculated by the Modification of Diet in Renal Disease formula.

resultsRegarding the HMOX1rs2071746, the estimated glomerular filtration rate median was significantly higher in TT patients (p=0.019), including when TT was compared with AT+AA (p=0.009); for the (GT)n repeats, the estimated glomerular filtration rate medians of SS, SL and LL significantly differed (p=0.009), being the LL estimated glomerular filtration rate median significantly higher, when compared with the LS+SS (p=0.005). These results suggest that both the homozygotes, TT for rs2071746 and LL for (GT)n repeats, lead to a higher risk of developing renal complications. Concerning the BMPR1B, the frequencies of GG for rs17022863 and AA for rs4331783 were significantly higher in patients than in controls (p=0.002 and p=0.008, respectively), however no association with estimated glomerular filtration rate was found.

conclusionThese results contribute to a better understanding of the genetic factors related to the development of nephropathy in sickle cell anemia patients.

Indexed as

Genetic polymorphismGlomerular filtration rateHeme oxygenase-1Oxidative stressSickle cell anemia

Identifiers

PMID32461055
PMCPMC8211626
OpenAlexW3024306648

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.