ArticleEpidemiology and psychiatric sciences2020
The overall and sex- and age-group specific incidence rates of cancer in people with schizophrenia: a population-based cohort study.
Article in Epidemiology and psychiatric sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Antipsychotic therapy and breast cancer risk: a comprehensive systematic review and meta-analysis.Breast cancer (Tokyo, Japan) · 2026Pooled it
- Clozapine and anti-cancer agents: a systematic literature review of case reports.CNS spectrums · 2025Pooled it
- Trial
- Concomitant pathologies and their impact on schizophrenia: a narrative overview of current evidence.Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
- Advancing Dimensional Models of Psychopathology in Cancer: Insights From Applying the Hierarchical Taxonomy of Psychopathology (HiTOP).Psycho-oncology · 2026Article
- Impact of Schizophrenia Spectrum Disorders on the Receipt of Invasive and Systemic Therapy for Colorectal Cancer: A Nationwide Multicenter Retrospective Cohort Study in Japan.Acta psychiatrica Scandinavica · 2026Article
- Breast cancer risk among women with schizophrenia and association with duration of antipsychotic use: population-based cohort study in South Korea.The British journal of psychiatry : the journal of mental science · 2025Article
- Aripiprazole use and lowering the risk of breast cancer in patient with schizophrenia in a national cohort study.PloS one · 2025Article
- Investigating the Relationship between Schizophrenia and Incidence Risk of Breast Cancer: A Systematic Review and Meta-Analysis of Cohort Studies.Iranian journal of psychiatry · 2024Review
- Turkish Adaptation of the Health Improvement Profile for the Evaluation of Physical Well-Being of Individuals With Severe Mental Illness.Florence Nightingale journal of nursing · 2024Article
- Relationship Between Clozapine and Non-Hematological Malignant Tumors: A Pharmacovigilance Analysis Using the FDA Adverse Event Reporting System Database.Drugs - real world outcomes · 2024Article
- The double burden of severe mental illness and cancer: a population-based study on colorectal cancer care pathways from screening to end-of-life care.Epidemiology and psychiatric sciences · 2024Article
- Medication Dosage Impact on Mortality in Old-Age Individuals with Schizophrenia: A National Cohort Study.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Genetic prediction of the causal relationship between schizophrenia and tumors: a Mendelian randomized study.Frontiers in oncology · 2024Article
- Psychiatric polygenic risk as a predictor of COVID-19 risk and severity: insight into the genetic overlap between schizophrenia and COVID-19.Translational psychiatry · 2023Article
- Breast Cancer Care Pathways for Women with Preexisting Severe Mental Disorders: Evidence of Disparities in France?Journal of clinical medicine · 2023Article
- Causal associations between schizophrenia and cancers risk: a Mendelian randomization study.Frontiers in oncology · 2023Article
- The Risk and The Course of Cancer Among People with Severe Mental Illness.Clinical practice and epidemiology in mental health : CP & EMH · 2023Review
- Deficient DNA base-excision repair in the forebrain leads to a sex-specific anxiety-like phenotype in mice.BMC biology · 2022Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsDecades of research show that people with schizophrenia have an increased risk of death from cancer; however, the relationship between schizophrenia and cancer incidence remains less clear. This population-based study investigates the incidence of seven common types of cancer among people with a hospital diagnosis of schizophrenia and accounting for the effects of age, sex and calendar time.
methodsThis population-based study used 1990-2013 data from three nationwide Swedish registries to calculate the incidence (in total, by age group and by sex) of any cancer and of lung, oesophageal, pancreatic, stomach, colon, (in men) prostate and (in women) breast cancer in 111 306 people with a hospital diagnosis of schizophrenia. The incidence in people with diagnosed schizophrenia was compared with the incidence in the general population. Risk estimates accounted for the effects of calendar time.
resultsIn 1 424 829 person-years of follow-up, schizophrenia did not confer an overall higher cancer risk (IRR 1.02, 95% CI 0.91-1.13) but was associated with a higher risk for female breast (IRR 1.19, 95% CI 1.12-1.26), lung (IRR 1.42, 95% CI 1.28-1.58), oesophageal (IRR 1.25, 95% CI 1.07-1.46) and pancreatic (IRR 1.10, 95% CI 1.01-1.21) and a lower risk of prostate (IRR 0.66, 95% CI 0.55-0.79) cancer. Some age- and sex-specific differences in risk were observed.
conclusionsPeople with schizophrenia do not have a higher overall incidence of cancer than people in the general population. However, there are significant differences in the risk of specific cancer types overall and by sex calling for efforts to develop disease-specific prevention programmes. In people with schizophrenia, higher risk generally occurs in those <75 years.
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