ArticleTranslational neurodegeneration2020
The compensatory phenomenon of the functional connectome related to pathological biomarkers in individuals with subjective cognitive decline.
Article in Translational neurodegeneration, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.
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Who cites it
48 citing papers in PubMed, 1 synthesis or guideline pooled it, 93 citations in OpenAlex.
- Global Alterations of Whole Brain Structural Connectome in Parkinson's Disease: A Meta-analysis.Neuropsychology review · 2023Pooled it
- Tai Chi modulating multimodal connectivity patterns and cognitive function in cerebral small vessel disease.GeroScience · 2026Trial
- Multi-networks connectivity at baseline predicts the clinical efficacy of left angular gyrus-navigated rTMS in the spectrum of Alzheimer's disease: A sham-controlled study.CNS neuroscience & therapeutics · 2023Trial
- Interpretable multimodal MRI fusion in Alzheimer's disease classification using extended parallel multilink joint ICA and 3D ResNet.iScience · 2026Article
- Incomplete network restoration may be associated with higher relapse risk in women with major depressive disorder.Psychiatry and clinical neurosciences · 2026Article
- Automatic identification of different stage of Alzheimer's disease using multimodal MRI and artificial intelligence.BMC medical imaging · 2026Article
- An exploratory study of altered regional homogeneity in Parkinson's disease with depression.Frontiers in psychiatry · 2026Article
- Prediction of treatment responsiveness to home-based transcranial photobiomodulation (tPBM) intervention for cognitive decline using fNIRS concurrently recorded during tPBM.Frontiers in aging neuroscience · 2026Article
- Memory Test Performance of People with Subjective Cognitive Decline Recruited From Different Settings: A Systematic Review and Meta-analysis.Neuropsychology review · 2025Review
- Identification of circadian-sensitive brain structure and its role in cognitive impairment and dementia.BMJ mental health · 2025Article
- Heterogeneous brain abnormalities in subjective cognitive decline converge on a common network and their transcriptional signature.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Association of precuneus Aβ burden with default mode network function.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Disruption of global brain network topology in amnestic MCI: evidence from multimodal DTI and fMRI.Frontiers in neuroscience · 2025Article
- Research progress on brain network imaging biomarkers of subjective cognitive decline.Frontiers in neuroscience · 2025Review
- Associations between the multitrajectory neuroplasticity of neuronavigated rTMS-mediated angular gyrus networks and brain gene expression in AD spectrum patients with sleep disorders.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Increased between-network connectivity: A risk factor for tau elevation and disease progression.Neuroscience letters · 2024Article
- Neuroimaging correlates of Alzheimer's disease biomarker concentrations in a racially diverse high-risk cohort of middle-aged adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Brain structure, amyloid, and behavioral features for predicting clinical progression in subjective cognitive decline.Human brain mapping · 2024Article
- The characteristic pattern of functional connectivity density influenced by postmenopausal females in the preclinical stage of dementia.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Prediction of disease progression in individuals with subjective cognitive decline using brain network analysis.CNS neuroscience & therapeutics · 2024Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundSubjective cognitive decline (SCD) is a preclinical stage along the Alzheimer's disease (AD) continuum. However, little is known about the aberrant patterns of connectivity and topological alterations of the brain functional connectome and their diagnostic value in SCD.
methodsResting-state functional magnetic resonance imaging and graph theory analyses were used to investigate the alterations of the functional connectome in 66 SCD individuals and 64 healthy controls (HC). Pearson correlation analysis was computed to assess the relationships among network metrics, neuropsychological performance and pathological biomarkers. Finally, we used the multiple kernel learning-support vector machine (MKL-SVM) to differentiate the SCD and HC individuals.
resultsSCD individuals showed higher nodal topological properties (including nodal strength, nodal global efficiency and nodal local efficiency) associated with amyloid-β levels and memory function than the HC, and these regions were mainly located in the default mode network (DMN). Moreover, increased local and medium-range connectivity mainly between the bilateral parahippocampal gyrus (PHG) and other DMN-related regions was found in SCD individuals compared with HC individuals. These aberrant functional network measures exhibited good classification performance in the differentiation of SCD individuals from HC individuals at an accuracy up to 79.23%.
conclusionThe findings of this study provide insight into the compensatory mechanism of the functional connectome underlying SCD. The proposed classification method highlights the potential of connectome-based metrics for the identification of the preclinical stage of AD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.