ArticleBMC pediatrics2020
Development and validation of bile acid profile-based scoring system for identification of biliary atresia: a prospective study.
Article in BMC pediatrics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.
- Concurrent biliary atresia and intestinal atresia: a systematic review of clinical characteristics, pathogenesis, management, and outcomes.Pediatric surgery international · 2026Pooled it
- Article
- Diagnostic value of routine biochemical markers for biliary atresia in neonates with cholestasis: a retrospective study.Translational pediatrics · 2026Article
- Diagnostic Scoring in Biliary Atresia.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2025Article
- Accurate prediction of biliary atresia with an integrated model using MMP-7 levels and bile acids.World journal of pediatrics : WJP · 2024Article
- Article
- Necroptosis of macrophage is a key pathological feature in biliary atresia via GDCA/S1PR2/ZBP1/p-MLKL axis.Cell death & disease · 2023Article
- Biliary Atresia in Children: Update on Disease Mechanism, Therapies, and Patient Outcomes.Clinics in liver disease · 2022Review
- Meconium Peritonitis, Intestinal Atresia Combined With Biliary Atresia: A Case Report.Frontiers in pediatrics · 2022Article
- Diagnostic Tools for Early Detection of Biliary Atresia: Is a Newborn Screen Attainable?Clinical liver disease · 2022Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundEarly distinguishing biliary atresia from other causes of infantile cholestasis remains a major challenge. We aimed to develop and validate a scoring system based on bile acid for identification of biliary atresia.
methodsIn a prospective study, a total of 141 infants with cholestasis were enrolled in two sets (derivation cohort, n = 66; validation cohort, n = 75) from 2014 to 2018. Variables with significant difference between biliary atresia and non-biliary atresia infants were selected in the derivation cohort. Then, a scoring system including those variables was designed and validated.
resultsAmong 66 patients in the derivation cohort, 34 (51.5%) had biliary atresia. A scoring system was proposed with the following variables: glycochenodeoxycholic acid/chenodeoxycholic acid, clay stool, and gamma-glutamyl transferase. The total score ranged from 0 to 41, and a cutoff value of 15 identified biliary atresia with an area under receiver operating characteristic curve of 0.87 (95% confidence interval, 0.77-0.94), sensitivity of 85.3%, and specificity of 81.3% in the derivation cohort; these values were also confirmed in a validation cohort with a sensitivity of 90.0% and specificity of 80.0%.
conclusionsThe proposed simple scoring system had good diagnostic accuracy for estimating the risk of biliary atresia in infants with cholestasis.
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