Evidence map›Paper›PMID 32460782›Full record

ArticleParticle and fibre toxicology2020

Toxicological evaluation of exhaust emissions from light-duty vehicles using different fuel alternatives in sub-freezing conditions.

Henri Hakkarainen, Päivi Aakko-Saksa, Maija Sainio, Tuukka Ihantola, Teemu J Rönkkö, Päivi Koponen, Topi Rönkkö, Pasi I Jalava

Abstract read
In one paragraph

Article in Particle and fibre toxicology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Henri HakkarainenInhalation toxicology laboratory, Department of Environmental and Biological Sciences, University of Eastern Finland, P.O. Box 1627, 70211, Kuopio, Finland. henri.hakkarainen@uef.fi.ORCID 0000-0002-8461-4565
Päivi Aakko-SaksaVTT Technical Research Centre of Finland, VTT, P.O. Box 1000, 02044, Espoo, Finland.
Maija SainioInhalation toxicology laboratory, Department of Environmental and Biological Sciences, University of Eastern Finland, P.O. Box 1627, 70211, Kuopio, Finland.
Tuukka IhantolaInhalation toxicology laboratory, Department of Environmental and Biological Sciences, University of Eastern Finland, P.O. Box 1627, 70211, Kuopio, Finland.
Teemu J RönkköInhalation toxicology laboratory, Department of Environmental and Biological Sciences, University of Eastern Finland, P.O. Box 1627, 70211, Kuopio, Finland.
Päivi KoponenVTT Technical Research Centre of Finland, VTT, P.O. Box 1000, 02044, Espoo, Finland.
Topi RönkköAerosol Physics Laboratory, Physics Unit, Tampere University, P.O. Box 692, 33014, Tampere, Finland.
Pasi I JalavaInhalation toxicology laboratory, Department of Environmental and Biological Sciences, University of Eastern Finland, P.O. Box 1627, 70211, Kuopio, Finland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEmissions from road traffic are under constant discussion since they pose a major threat to human health despite the increasingly strict emission targets and regulations. Although the new passenger car regulations have been very effective in reducing the particulate matter (PM) emissions, the aged car fleet in some EU countries remains a substantial source of PM emissions. Moreover, toxicity of PM emissions from multiple new types of bio-based fuels remain uncertain and different driving conditions such as the sub-zero running temperature has been shown to affect the emissions. Overall, the current literature and experimental knowledge on the toxicology of these PM emissions and conditions is scarce.

methodsIn the present study, we show that exhaust gas PM from newly regulated passenger cars fueled by different fuels at sub-zero temperatures, induce toxicological responses in vitro. We used exhaust gas volume-based PM doses to give us better insight on the real-life exposure and included one older diesel car to estimate the effect of the new emissions regulations.

resultsIn cars compliant with the new regulations, gasoline (E10) displayed the highest PM concentrations and toxicological responses, while the higher ethanol blend (E85) resulted in slightly lower exhaust gas PM concentrations and notably lower toxicological responses in comparison. Engines powered by modern diesel and compressed natural gas (CNG) yielded the lowest PM concentrations and toxicological responses.

conclusionsThe present study shows that toxicity of the exhaust gas PM varies depending on the fuels used. Additionally, concentration and toxicity of PM from an older diesel car were vastly higher, compared to contemporary vehicles, indicating the beneficial effects of the new emissions regulations.

Indexed as

GasolineAir PollutantsEnvironmental MonitoringEuropean UnionFreezingGovernment RegulationHumansMotor VehiclesParticulate MatterVehicle EmissionsAir PollutantsGasolineParticulate MatterVehicle EmissionsCompressed natural gasDieselEmissionsGasolineIn vitro toxicologyParticulate matter

Identifiers

PMID32460782
PMCPMC7251820

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.