Evidence map›Paper›PMID 32460756›Full record

ArticleBMC veterinary research2020

Lagovirus europeus GI.2 (rabbit hemorrhagic disease virus 2) infection in captive mountain hares (Lepus timidus) in Germany.

Melanie Buehler, Sonja T Jesse, Heike Kueck, Bastian Lange, Patricia Koenig, Wendy K Jo, Albert Osterhaus, Andreas Beineke

Open access · goldAbstract read
In one paragraph

Article in BMC veterinary research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.4field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 21 citations in OpenAlex.

  1. Rabbit hemorrhagic disease virus 2, 2010-2023: a review of global detections and affected species.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2024
    Review
  2. Characterisation ofInternational journal of molecular sciences · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Melanie BuehlerInstitute of Pathology, University of Veterinary Medicine Hanover, Foundation, Buenteweg, 17 30559, Hannover, Germany.
Sonja T JesseResearch Center for Emerging Infections and Zoonoses, University of Veterinary Medicine Hanover, Foundation, Buenteweg, 17 30559, Hannover, Germany.
Heike KueckZoo am Meer Bremerhaven, H.-H.-Meier-Straße 7, 27568, Bremerhaven, Germany.
Bastian LangeZoo am Meer Bremerhaven, H.-H.-Meier-Straße 7, 27568, Bremerhaven, Germany.
Patricia KoenigInstitute of Diagnostic Virology, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Suedufer 10, 17493, Greifswald, Insel Riems, Germany.
Wendy K JoResearch Center for Emerging Infections and Zoonoses, University of Veterinary Medicine Hanover, Foundation, Buenteweg, 17 30559, Hannover, Germany.
Albert OsterhausResearch Center for Emerging Infections and Zoonoses, University of Veterinary Medicine Hanover, Foundation, Buenteweg, 17 30559, Hannover, Germany.
Andreas BeinekeInstitute of Pathology, University of Veterinary Medicine Hanover, Foundation, Buenteweg, 17 30559, Hannover, Germany. andreas.beineke@tiho-hannover.de.ORCID http://orcid.org/0000-0003-2187-3436
University of Veterinary Medicine Hannover, Foundation · DEFriedrich-Loeffler-Institut · DE

Funding

Deutsche Forschungsgemeinschaft 398066876/GRK 2485/1Niedersächsisches Ministerium für Wissenschaft und Kultur Niedersachsen-Research Network on Neuroinfectiology (N-RENNT)
6 · The paper itself

Abstract

backgroundRabbit hemorrhagic disease virus (RHDV, Lagovirus europeus GI.1) induces a contagious and highly lethal hemorrhagic disease in rabbits. In 2010 a new genotype of lagovirus (GI.2), emerged in Europe, infecting wild and domestic population of rabbits and hares. CASE PRESENTATION: We describe the infection with a GI.2 strain, "Bremerhaven-17", in captive mountain hares (Lepus timidus) in a zoo facility in Germany. Postmortem examination revealed RHD-like lesions including necrotizing hepatitis. RT-qPCR and AG-ELISA confirmed presence of GI.2. Recombination and phylogenetic analysis grouped the identified strain with other GI.2 strains, sharing nucleotide identity of 91-99%.

conclusionOur findings confirm that mountain hares are susceptible to GI.2 infection, due to a past recombination event facilitating virus spillover from sympatric rabbits.

Indexed as

AnimalsCaliciviridae InfectionsDisease OutbreaksEnzyme-Linked Immunosorbent AssayFemaleGermanyHaresHemorrhagic Disease Virus, RabbitMalePhylogenyReal-Time Polymerase Chain ReactionCaliciviridaeEmerging infectionGI.2LagovirusLeporidaePhylogenetic analysisRabbit hemorrhagic disease virus 2RHDV2

Identifiers

PMID32460756
PMCPMC7254734
OpenAlexW3032407673

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.