Evidence map›Paper›PMID 32460741›Full record

ArticleBMC urology2020

A prospective observational cohort study of posterior tibial nerve stimulation in patients with multiple sclerosis: design and methods.

Giulia I Lane, Yang Mao-Draayer, Paholo Barboglio-Romo, J Quentin Clemens, Priyanka Gupta, Rod Dunn, Yongmei Qin, Anne P Cameron, John T Stoffel

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC urology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04063852 (Impact of Percutaneous Posterior Tibial Nerve Stimulation on Urinary and Global Quality of Life in Multiple Sclerosis Patients), which is not on this map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04063852 completednot on this map

Impact of Percutaneous Posterior Tibial Nerve Stimulation on Urinary and Global Quality of Life in Multiple Sclerosis Patients

TypeobservationalSponsorUniversity of MichiganRan2019 to 2022Enrolled23ConditionsMultiple Sclerosis, Lower Urinary Tract Symptoms, Neurogenic Bladder, Overactive Bladder
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Observational
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Giulia I LaneDepartment of Urology, University of Michigan, 1500 East Medical Drive, Taubman Center 3875, Ann Arbor, MI, 48109, USA. giuliala@med.umich.edu.ORCID http://orcid.org/0000-0002-6977-5280
Yang Mao-DraayerDepartment of Neurology, University of Michigan, Ann Arbor, MI, USA.
Paholo Barboglio-RomoDepartment of Urology, University of Michigan, 1500 East Medical Drive, Taubman Center 3875, Ann Arbor, MI, 48109, USA.
J Quentin ClemensDepartment of Urology, University of Michigan, 1500 East Medical Drive, Taubman Center 3875, Ann Arbor, MI, 48109, USA.
Priyanka GuptaDepartment of Urology, University of Michigan, 1500 East Medical Drive, Taubman Center 3875, Ann Arbor, MI, 48109, USA.
Rod DunnDepartment of Urology, University of Michigan, 1500 East Medical Drive, Taubman Center 3875, Ann Arbor, MI, 48109, USA.
Yongmei QinDepartment of Urology, University of Michigan, 1500 East Medical Drive, Taubman Center 3875, Ann Arbor, MI, 48109, USA.
Anne P CameronDepartment of Urology, University of Michigan, 1500 East Medical Drive, Taubman Center 3875, Ann Arbor, MI, 48109, USA.
John T StoffelDepartment of Urology, University of Michigan, 1500 East Medical Drive, Taubman Center 3875, Ann Arbor, MI, 48109, USA.
University of Michigan · US

Funding

Society of Urodynamics, Female Pelvic Medicine and Urogenital Reconstruction Foundation AWD011295, 2018 Study of Neuromodulation funded by Medtronic
6 · The paper itself

Abstract

backgroundPosterior tibial nerve stimulation (PTNS) is a promising treatment for lower urinary tract symptoms (LUTS) in patients with MS. However, long term data focusing on PTNS impact on health-related quality of life (HRQOL), bowel and bladder symptoms are lacking. This paper describes a study protocol that examines the extended efficacy of PTNS on MS related bladder and bowel symptoms and resulting HRQOL. METHODS/

designThis is a single-centered, prospective, longitudinal, observational cohort study of patients with MS who suffer from LUTS and are refractory to two prior treatment modalities. Participants who have elected to pursue PTNS therapy for LUTS will be eligible. The primary outcome is the median number of urinary frequency and incontinence episodes on a 3-day voiding diary at 3, 12 and 24 months compared to baseline. Secondary outcome measures will include change in total AUA-SS, M-ISI, NBSS, SF-12, SSS and BCS scores from baseline The Expanded Disability Status Scale and magnetic resonance imaging will be evaluated at baseline and annually throughout the study. DISCUSSION: This research protocol aims to expand on the existing literature regarding outcomes of PTNS in MS. Specifically, it will provide long term follow-up data on bladder, bowel, sexual and HRQOL outcomes. The completion of this study will provide longitudinal efficacy data of the impact of PTNS in MS patients.

trial registrationNCT04063852.

Indexed as

Quality of LifeTranscutaneous Electric Nerve StimulationCohort StudiesHumansLongitudinal StudiesLower Urinary Tract SymptomsMultiple SclerosisObservational Studies as TopicProspective StudiesResearch DesignTibial NerveMultiple sclerosisNeurogenicNeuromodulationProspective studiesQuality of lifeTibial nerveUrinary bladderUrinary incontinence

Identifiers

PMID32460741
PMCPMC7251681
OpenAlexW3031715947

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.