Evidence map›Paper›PMID 32460641›Full record

ArticleTissue engineering. Part A2021

Evaluation of Bilayer Silk Fibroin Grafts for Tubular Esophagoplasty in a Porcine Defect Model.

Gokhan Gundogdu, Duncan Morhardt, Vivian Cristofaro, Khalid Algarrahi, Xuehui Yang, Kyle Costa, Cinthia Galvez Alegria, Maryrose P Sullivan, Joshua R Mauney

Open access · greenAbstract read
In one paragraph

Article in Tissue engineering. Part A, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Silk fibroin-based scaffolds for tissue engineering.Frontiers in bioengineering and biotechnology · 2024
    Review
  6. Tissue Engineering for Gastrointestinal and Genitourinary Tracts.International journal of molecular sciences · 2022
    Review
  7. Development and Prospect of Esophageal Tissue Engineering.Frontiers in bioengineering and biotechnology · 2022
    Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Gokhan GundogduDepartments of Urology and Biomedical Engineering, University of California, Irvine, Orange, California, USA.
Duncan MorhardtUrological Diseases Research Center, Boston Children's Hospital, Boston, Massachusetts, USA.
Vivian CristofaroDepartment of Surgery, Harvard Medical School, Boston, Massachusetts, USA.
Khalid AlgarrahiUrological Diseases Research Center, Boston Children's Hospital, Boston, Massachusetts, USA.
Xuehui YangUrological Diseases Research Center, Boston Children's Hospital, Boston, Massachusetts, USA.
Kyle CostaUrological Diseases Research Center, Boston Children's Hospital, Boston, Massachusetts, USA.
Cinthia Galvez AlegriaUrological Diseases Research Center, Boston Children's Hospital, Boston, Massachusetts, USA.
Maryrose P SullivanDepartment of Surgery, Harvard Medical School, Boston, Massachusetts, USA.
Joshua R MauneyDepartments of Urology and Biomedical Engineering, University of California, Irvine, Orange, California, USA.
Boston Children's Hospital · USHarvard University · USVA Boston Healthcare System · US

Funding

Translational Bioreactors - Engineering Complex TissuesP41EB002520 · NIBIB · TUFTS UNIVERSITY MEDFORD · PI KAPLAN, DAVID L. · 2004 to 2018
$16.7M
Development of Silk Fibroin Grafts for Reconstruction of Esophageal DefectsR01DK107568 · NIDDK · UNIVERSITY OF CALIFORNIA-IRVINE · PI ESTRADA, CARLOS R, MAUNEY, JOSHUA ROBERT · 2016 to 2020
$1.9M
NIBIB NIH HHS P41 EB002520NIDDK NIH HHS R01 DK107568
6 · The paper itself

Abstract

Surgical reconstruction of tubular esophageal defects with autologous gastrointestinal segments is the gold standard treatment to replace damaged or diseased esophageal tissues. Unfortunately, this approach is associated with adverse complications, including dysphagia, donor-site morbidity, and in some cases patient death. Bilayer silk fibroin (BLSF) scaffolds were investigated as alternative, acellular grafts for tubular esophagoplasty in a porcine defect model for 3 months of implantation. Adult Yucatan mini-swine (

Indexed as

EsophagoplastyFibroinsAnimalsRegenerationSilkSwineTissue EngineeringTissue ScaffoldsFibroinsSilkesophagussilk fibroin scaffoldstissue engineering

Identifiers

PMID32460641
PMCPMC7826443
OpenAlexW3030795697

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.