Observational studyArteriosclerosis, thrombosis, and vascular biology2020
Sex-Specific Regulation of Inflammation and Metabolic Syndrome in Obesity.
Observational study in Arteriosclerosis, thrombosis, and vascular biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
85 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Pooled it
- Replication and mediation of the association between the metabolome and clinical markers of metabolic health in an adolescent cohort study.Scientific reports · 2023Pooled it
- Transethnic meta-analysis of exome-wide variants identifies new loci associated with male-specific metabolic syndrome.Genes & genomics · 2022Pooled it
- Traditional Cardiovascular Risk Factors Are Stronger Related to Carotid Intima-Media Thickness Than to Presence of Carotid Plaques in People Living With HIV.Journal of the American Heart Association · 2023Trial
- Whole-body and intracellular arginine metabolism in hypertension: role of disease severity and sex.American journal of hypertension · 2026Observational
- Association between platelet/high-density lipoprotein cholesterol ratio and incidence of coronary heart disease: insights from the UK Biobank.BMC cardiovascular disorders · 2026Article
- Gender-specific associations of diet quality and dietary patterns with metabolic syndrome: evidence from Korea National Health and Nutrition Examination Survey (KNHANES) VI.Nutrition & metabolism · 2026Article
- The Use of Spice Herbs May Reduce Chronic Inflammation and Improve the Quality of Life of Women with Metabolic Syndrome-A Narrative Review.Nutrients · 2026Review
- Sex Differences in Dietary-Induced Liver Steatosis and Insulin Receptor-Related Signaling in Aged Mice Lacking Serotonin Transporter.International journal of molecular sciences · 2026Article
- Sex-biased plasma inflammatory protein profile in obesity.Scientific reports · 2026Article
- Sex Differences in the Impact of Obesity on Immunity.Immunological reviews · 2026Review
- Hyperglycemia impairs the expression of inflammatory mediators in rat intestine: an implication for intestinal inflammation and inflammatory bowel disease.Molecular and cellular biochemistry · 2026Article
- Estradiol treatment induces both shared and unique gene regulation and networks in adipose cell types of gonadectomized obese XX and XY mice.Biology of sex differences · 2026Article
- Consumption of Ultra-Processed Foods and Biochemical Markers Predictive of Type 2 Diabetes Mellitus in a Self-Selected Pilot Sample of Muslim Adolescents in Melilla.Foods (Basel, Switzerland) · 2026Article
- Urinary Proteomics as a Noninvasive Readout of Obesity-associated Inflammation.Journal of the Endocrine Society · 2026Article
- Trends and factors associated with liver fibrosis-cirrhosis complicated with pneumonia-influenza mortality in U.S. Counties: a CDC WONDER and CHR database analysis.Frontiers in public health · 2026Article
- Associations between C-reactive protein-triglyceride glucose index and asthma risk among Chinese adults: evidence from the CHARLS cohort and external hospital-based validation.Frontiers in immunology · 2026Article
- Trained Immunity and Cardiovascular Risk: An Immunological Perspective.Immunological reviews · 2026Review
- Sex specific pattern of adipose expansion, inflammation and dysfunction with short term high fat diet exposure.Frontiers in endocrinology · 2026Article
- Gender differences in adiponectin levels among obese individuals and their association with cardiovascular disease.Frontiers in cell and developmental biology · 2026Review
25 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveMetabolic dysregulation and inflammation are important consequences of obesity and impact susceptibility to cardiovascular disease. Anti-inflammatory therapy in cardiovascular disease is being developed under the assumption that inflammatory pathways are identical in women and men, but it is not known if this is indeed the case. In this study, we assessed the sex-specific relation between inflammation and metabolic dysregulation in obesity. Approach and Results: Three hundred two individuals were included, half with a BMI 27 to 30 kg/m
conclusionsWe identified sex-specific pathways that influence inflammation in obesity. Excessive production of proinflammatory cytokines was observed in men with metabolic syndrome. In contrast, women typically showed reduced levels of the anti-inflammatory adipokine adiponectin. These different mechanisms of inflammatory dysregulation between women and men with obesity argue for sex-specific therapeutic strategies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.