Evidence map›Paper›PMID 32460513›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2020

Glucocorticoid regulates mesenchymal cell differentiation required for perinatal lung morphogenesis and function.

James P Bridges, Parvathi Sudha, Dakota Lipps, Andrew Wagner, Minzhe Guo, Yina Du, Kari Brown, Alyssa Filuta, Joseph Kitzmiller, Courtney Stockman and 5 more

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
3.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.

  1. Pooled it
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  4. Article
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  6. Article
  7. Article
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  9. Article
  10. Article
  11. R-SPONDIN2Developmental cell · 2022
    Article
  12. Article
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  14. Article
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  16. Alveologenesis: What Governs Secondary Septa Formation.International journal of molecular sciences · 2021
    Review
  17. Article
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  19. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 2 countries.

James P BridgesPerinatal Institute, Section of Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Parvathi SudhaPerinatal Institute, Section of Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Dakota LippsCollege of Engineering and Applied Science, University of Cincinnati, Cincinnati, Ohio.
Andrew WagnerCollege of Engineering and Applied Science, University of Cincinnati, Cincinnati, Ohio.
Minzhe GuoPerinatal Institute, Section of Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Yina DuPerinatal Institute, Section of Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.ORCID 0000-0003-1378-8821
Kari BrownPerinatal Institute, Section of Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Alyssa FilutaPerinatal Institute, Section of Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Joseph KitzmillerPerinatal Institute, Section of Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Courtney StockmanPerinatal Institute, Section of Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Xiaoting ChenCenter for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Matthew T WeirauchDepartment of Pediatrics, University of Cincinnati School of Medicine, Cincinnati, Ohio.
Alan H JobePerinatal Institute, Section of Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Jeffrey A WhitsettPerinatal Institute, Section of Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Yan XuPerinatal Institute, Section of Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.ORCID 0000-0003-2025-027X
Cincinnati Children's Hospital Medical Center · USUniversity of Cincinnati · US

Funding

LungMap Phase II - Building a multidimensional map of developing human lungU01HL148856 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI WHITSETT, JEFFREY A, XU, YAN · 2019 to 2023
$4.5M
"Lung MAP" Atlas Research CenterU01HL122642 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI POTTER, S. STEVEN, WHITSETT, JEFFREY A · 2014 to 2018
$3.9M
Uterine signaling networks in the pathogenesis of pulmonary lymphangioleiomyomatosis (LAM)R01HL153045 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI XU, YAN, YU, JANE · 2020 to 2023
$3.1M
Role of GPR116 in Alveolar HomeostasisR01HL131634 · NHLBI · NATIONAL JEWISH HEALTH · PI BRIDGES, JAMES PATRICK · 2016 to 2020
$2.0M
Role of SREBP Network in Surfactant Lipid Homeostasis and Lung MaturationR01HL105433 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI XU, YAN · 2011 to 2014
$1.8M
HHS | NIH | National Heart, Lung, and Blood Institute (NHBLI) HL131634HHS | NIH | National Heart, Lung, and Blood Institute (NHBLI) U01HL122642NHLBI NIH HHS R01 HL105433NHLBI NIH HHS R01 HL131634NHLBI NIH HHS R01 HL153045NHLBI NIH HHS U01 HL122642NHLBI NIH HHS U01 HL148856
6 · The paper itself

Abstract

While antenatal glucocorticoids are widely used to enhance lung function in preterm infants, cellular and molecular mechanisms by which glucocorticoid receptor (GR) signaling influences lung maturation remain poorly understood. Deletion of the glucocorticoid receptor gene (

Indexed as

Alveolar Epithelial CellsAnimalsCell DifferentiationCell ProliferationFibroblastsGlucocorticoidsLungMesenchymal Stem CellsMiceMice, Inbred C57BLReceptors, GlucocorticoidSignal TransductionGlucocorticoidsReceptors, Glucocorticoidglucocorticoid signalingmatrix fibroblastregulatory network systems biologysingle cell

Identifiers

PMID32460513
PMCPMC7473939
OpenAlexW3031256964

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.