ArticleNeurourology and urodynamics2020
Daily salt intake is associated with leg edema and nocturnal urinary volume in elderly men.
Article in Neurourology and urodynamics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed, 9 citations in OpenAlex.
- Model of Nocturnal Polyuria in Older Japanese Adults Receiving Enteral Nutrition in Medical Long-Term Care Hospitals: An Exploratory Cross-Sectional Study.Lower urinary tract symptoms · 2026Observational
- The Influence of Dietary Habits on Male Lower Urinary Tract Symptoms: Differential Influence of Water Intake on Voiding Symptoms and Storage Symptoms.The world journal of men's health · 2025Article
- Analysis of Nocturia Determinants Using a Novel Portable Urine-Measuring Device.Neurourology and urodynamics · 2025Article
- Oxidative stress-induced NCC activation in the development of nocturnal polyuria in mice: Therapeutic potential of a sustained hydrogen-releasing silicon-based agent.Biochemistry and biophysics reports · 2025Article
- Canadian Urological Association best practice report: Diagnosis and management of nocturia.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2022Article
- Dietary salt with nitric oxide deficiency induces nocturnal polyuria in mice via hyperactivation of intrarenal angiotensin II-SPAK-NCC pathway.Communications biology · 2022Article
- Association between sodium or salt intake and lower urinary tract symptoms: a systematic review.Therapeutic advances in urologyReview
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Authors and funding
10 authors at 4 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
aimsThere is accumulating evidence that excessive salt intake contributes to nocturnal polyuria. We aimed to investigate the relationship between salt intake, leg edema, and nocturnal urine volume (NUV) to assess the etiology of nocturnal polyuria.
methodsA total of 56 men aged ≥60 years who were hospitalized for benign prostatic hyperplasia or with suspected prostatic cancer were enrolled. Urine frequency-volume charts of the patients were maintained, and they underwent bioelectrical impedance analysis twice daily (at 5:00 pm and 6:00 am) and examination of blood (brain natriuretic peptide levels) and urine (sodium and creatinine levels and osmotic pressure) samples once daily (at 6:00 am). Free-water clearance, solute clearance, and sodium clearance at night were measured, and daily salt intake was estimated.
resultsThe data of 52 patients were analyzed. Daily salt intake positively correlated with leg edema at 5:00 pm, differences in leg extracellular fluid levels between 5:00 pm and 6:00 am, and NUV, but not with diurnal urine volume. Partial correlation coefficients showed that salt intake was a factor of the correlation between NUV and change in extracellular volume in the legs between 5:00 pm and 6:00 am. A multivariate logistic model showed that sleep duration and sodium clearance were independent predictive factors for nocturnal polyuria.
conclusionsSodium intake correlates with diurnal leg edema and NUV in elderly men. These results provide evidence supporting sodium restriction as an effective treatment for nocturnal polyuria.
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