ArticleSeminars in arthritis and rheumatism2020
Patterns of clinical presentation in Takayasu's arteritis.
Article in Seminars in arthritis and rheumatism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 52 citations in OpenAlex.
- Takayasu Arteritis Presenting With Cardiac Arrest: An Intravascular Imaging Triggered Diagnosis.JACC. Case reports · 2026Article
- A Silent Vasculitis With a Loud Presentation: Takayasu Arteritis Causing Intracerebral Hemorrhage.Cureus · 2026Article
- Biomarkers in Primary Systemic Vasculitides: Narrative Review.International journal of molecular sciences · 2026Review
- A Case of Isolated Aortic Regurgitation, Later Diagnosed as Takayasu Arteritis: An Importance of Physical Examinations.Clinical case reports · 2025Article
- Advances in the pathophysiology, diagnosis and treatment of Takayasu arteritis.Nature reviews. Rheumatology · 2025Review
- Lymphoproliferative Disorders Mimicking Rheumatologic Disease: A Clinical Reasoning Perspective.Current allergy and asthma reports · 2025Review
- Takayasu arteritis masquerading as brucellosis: a case report.Oxford medical case reports · 2024Article
- Carotidynia as the First Manifestation of Takayasu Arteritis: Report of Two Cases and a Brief Review of Literature.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2024Article
- Article
- A Glimpse into Humoral Response and Related Therapeutic Approaches of Takayasu's Arteritis.International journal of molecular sciences · 2024Review
- Development of the Takayasu Arteritis Integrated Disease Activity Index.Arthritis care & research · 2024Review
- Risk factors and prognosis of depression in Takayasu arteritis patients.Therapeutic advances in musculoskeletal disease · 2024Article
- Are monocyte-to-HDL and C-reactive protein-to-albumin ratios useful for the diagnosis and follow-up of Takayasu arteritis?Revista da Associacao Medica Brasileira (1992) · 2024Article
- Pre-Pulseless Takayasu Arteritis is Associated with Distinct Clinical and Angiographic Features but Similar Outcomes - A Cohort Study.Mediterranean journal of rheumatology · 2023Article
- Article
- Ischemic stroke at first presentation of Takayasu arteritis in a young African male from Kenya, East Africa: Case report and brief literature review.Clinical case reports · 2023Article
- Advanced molecular imaging in large-vessel vasculitis: Adopting FDG-PET into a clinical workflow.Best practice & research. Clinical rheumatology · 2023Review
- Impact of Geographic Location on Diagnosis and Initial Management of Takayasu Arteritis: A Tale of Two Cohorts from Italy and India.Diagnostics (Basel, Switzerland) · 2022Article
- Comparison of Presentation and Prognosis of Takayasu Arteritis with or without Stroke or Transient Ischemic Attack-A Retrospective Cohort Study.Life (Basel, Switzerland) · 2022Article
- Use of 18F-fluorodeoxyglucose positron emission tomography to standardize clinical trial recruitment in Takayasu's arteritis.Rheumatology (Oxford, England) · 2022Observational
Corrections and comments
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Authors and funding
18 authors at 12 institutions in 1 country.
Funding
Abstract
objectiveTakayasu's arteritis (TAK) is a clinically heterogenous disease. Patterns of clinical presentation in TAK at diagnosis have not been well described, and a "triphasic pattern" of constitutional symptoms evolving into vascular inflammation and fibrosis has been reported but never systematically evaluated.
methodsPatients with TAK were prospectively recruited from the National Institutes of Health (NIH) and the Vasculitis Clinical Research Consortium (VCRC). Based on clinical presentation at diagnosis, patients were divided into five categories: (1) constitutional symptoms alone, (2) carotidynia, (3) other vascular-associated symptoms, (4) major ischemic event, or (5) asymptomatic. Associated clinical characteristics were evaluated in each category. Preceding symptoms were also assessed to determine the presence of a triphasic disease pattern.
resultsA total of 275 patients with TAK were included (VCRC=208; NIH=67). Similar heterogeneity of clinical presentation was identified in each cohort: constitutional symptoms (8%), carotidynia (13-15%), other vascular symptoms (43-47%), major ischemic event (28-30%), and asymptomatic (2-6%). An increased relative proportion of males was seen in patients who presented with constitutional symptoms or were asymptomatic at diagnosis (p<0.01). Patients who presented with constitutional symptoms and major ischemic events were youngest at diagnosis. Patients in the asymptomatic group were oldest at diagnosis and often were not treated (p<0.01). Relapse was most frequent in patients who presented with carotidynia (p<0.01). A minority of patients (19%) who presented with a major ischemic event reported a triphasic pattern of disease.
conclusionThere are diverse clinical presentations at diagnosis in TAK. Patients do not necessarily progress sequentially through phases of disease.
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