ReviewTrends in neurosciences2020
Impacts of Sleep Loss versus Waking Experience on Brain Plasticity: Parallel or Orthogonal?
Review in Trends in neurosciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 46 citations in OpenAlex.
- Sleep deprivation increases levels of the synaptic density marker SV2A in the human brain.PLoS biology · 2026Trial
- Review
- Microglial response to sleep deprivation depends on the hippocampal region and paradigm used in adult male mice.Brain, behavior, & immunity - health · 2026Article
- Does It Matter What Keeps You Awake? Effects of Two Different Sleep Deprivation Methods on Object-Location Memory and Hippocampal c-Fos Expression in Mice.Journal of sleep research · 2026Article
- Article
- Article
- A unified framework to model synaptic dynamics during the sleep-wake cycle.PLoS biology · 2025Article
- Introduction of novel objects to the home cage of mice repeatedly disturbs sleep for seven days with minimal stress induction.Npj biological timing and sleep · 2025Article
- Brief sleep disruption alters synaptic structures among hippocampal and neocortical somatostatin-expressing interneurons.bioRxiv : the preprint server for biology · 2025Article
- Sleep maintains excitatory synapse diversity in the cortex and hippocampus.Current biology : CB · 2024Article
- Sleep-dependent engram reactivation during hippocampal memory consolidation associated with subregion-specific biosynthetic changes.iScience · 2024Article
- Structural neuroplasticity after sleep loss modifies behavior and requires neurexin and neuroligin.iScience · 2024Article
- Overnight neuronal plasticity and adaptation to emotional distress.Nature reviews. Neuroscience · 2024Review
- Sleep restores an optimal computational regime in cortical networks.Nature neuroscience · 2024Article
- Article
- Enriched binocular experience followed by sleep optimally restores binocular visual cortical responses in a mouse model of amblyopia.Communications biology · 2023Article
- Article
- FABP7: a glial integrator of sleep, circadian rhythms, plasticity, and metabolic function.Frontiers in systems neuroscience · 2023Article
- Sleep deprivation reduces the density of individual spine subtypes in a branch-specific fashion in CA1 neurons.Journal of sleep research · 2022Article
- Microglia modulate hippocampal synaptic transmission and sleep duration along the light/dark cycle.Glia · 2022Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Recent studies on the effects of sleep deprivation on synaptic plasticity have yielded discrepant results. Sleep deprivation studies using novelty exposure as a means to keep animals awake suggests that sleep (compared with wake) leads to widespread reductions in net synaptic strength. By contrast, sleep deprivation studies using approaches avoiding novelty-induced arousal (i.e., gentle handling) suggest that sleep can promote synaptic growth and strengthening. How can these discrepant findings be reconciled? Here, we discuss how varying methodologies for the experimental disruption of sleep (with differential introduction of novel experiences) could fundamentally alter the experimental outcome with regard to synaptic plasticity. Thus, data from experiments aimed at assessing the relative impact of sleep versus wake on the brain may instead reflect the quality of the waking experience itself. The highlighted work suggests that brain plasticity resulting from novel experiences versus wake per se has unique and distinct features.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.