ReviewTrends in neurosciences2020
Noisy Synaptic Conductance: Bug or a Feature?
Review in Trends in neurosciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 78 citations in OpenAlex.
- Signal-Dependent Planning Noise Reduces Task Interference by Assisting in the Formation of Stable Motor Primitives in a Neural Network Model of Muscle Coordination Learning.Neural computation · 2026Article
- Metaplastic sleep regulation inbioRxiv : the preprint server for biology · 2026Article
- A heterogeneous population code at the first synapse of vision.Nature communications · 2026Article
- Beyond synaptic plasticity: a summary of a linear model of the cerebellar locomotor computation.Frontiers in neural circuits · 2026Review
- Adaptive proximity to criticality underlies amplification of ultra-slow fluctuations during free recall.PLoS computational biology · 2025Article
- Quantifying the link between retinal performance and the optomotor response.Current biology : CB · 2025Article
- Inferring synaptic transmission from the stochastic dynamics of the quantal content: An analytical approach.PLoS computational biology · 2025Article
- Beyond Mechanism-Extending Our Concepts of Causation in Neuroscience.The European journal of neuroscience · 2025Review
- Spike reliability is cell type specific and shapes excitation and inhibition in the cortex.Scientific reports · 2025Article
- Metastable dynamics emerge from local excitatory-inhibitory homeostasis in the cortex at rest.Network neuroscience (Cambridge, Mass.) · 2025Article
- Sparse connectivity enables efficient information processing in cortex-like artificial neural networks.Frontiers in neural circuits · 2025Article
- Substance P and dopamine form a "push-pull" system that diurnally regulates retinal gain.Current biology : CB · 2024Article
- Synapses learn to utilize stochastic pre-synaptic release for the prediction of postsynaptic dynamics.PLoS computational biology · 2024Article
- Human-specific genetic modifiers of cortical architecture and function.Current opinion in genetics & development · 2024Review
- Spike Reliability is Cell-Type Specific and Shapes Excitation and Inhibition in the Cortex.bioRxiv : the preprint server for biology · 2024Article
- Sampling-based Bayesian inference in recurrent circuits of stochastic spiking neurons.Nature communications · 2023Article
- The adaptive stochasticity hypothesis: Modeling equifinality, multifinality, and adaptation to adversity.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Functional integrity of visual coding following advanced photoreceptor degeneration.Current biology : CB · 2023Article
- The Impact of Multivesicular Release on the Transmission of Sensory Information by Ribbon Synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Diurnal changes in the efficiency of information transmission at a sensory synapse.Nature communications · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
More often than not, action potentials fail to trigger neurotransmitter release. And even when neurotransmitter is released, the resulting change in synaptic conductance is highly variable. Given the energetic cost of generating and propagating action potentials, and the importance of information transmission across synapses, this seems both wasteful and inefficient. However, synaptic noise arising from variable transmission can improve, in certain restricted conditions, information transmission. Under broader conditions, it can improve information transmission per release, a quantity that is relevant given the energetic constraints on computing in the brain. Here we discuss the role, both positive and negative, synaptic noise plays in information transmission and computation in the brain.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.