Evidence map›Paper›PMID 32459508›Full record

ArticleExperimental biology and medicine (Maywood, N.J.)2018

Buformin increases radiosensitivity in cervical cancer cells via cell-cycle arrest and delayed DNA-damage repair.

Ling Chen, Ting Zhang, Qiuli Liu, Mei Tang, Yu'e Yang, Yuan Wang, Haifeng Qiu, Jinjin Yu

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental biology and medicine (Maywood, N.J.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Ling ChenDepartment of Gynecology, Affiliated Hospital of Jiangnan University, Wuxi 214062, China.
Ting ZhangDepartment of Gynecology, Affiliated Hospital of Jiangnan University, Wuxi 214062, China.
Qiuli LiuWuxi Medical College, Jiangnan University, Wuxi 214000, China.
Mei TangDepartment of Gynecology, Affiliated Hospital of Jiangnan University, Wuxi 214062, China.
Yu'e YangDepartment of Gynecology, Affiliated Hospital of Jiangnan University, Wuxi 214062, China.
Yuan WangDepartment of Gynecology, Affiliated Hospital of Jiangnan University, Wuxi 214062, China.
Haifeng QiuDepartment of Gynecology, the First Affiliated Hospital of Zhengzhou University, Zhenzhou 450052, China.
Jinjin YuDepartment of Gynecology, Affiliated Hospital of Jiangnan University, Wuxi 214062, China.
Wuxi Fourth People's Hospital · CNJiangnan University · CNFirst Affiliated Hospital of Zhengzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

impact statementOur idea originated in the thought of discovering new effects of old drugs. Although this study is a basic research, it is very close to clinical treatment. Flow cytometry and immunofluorescence were used to verify that buformin increases radiosensitivity. We aimed to address one of the thorniest problems in treatment process. Based on discovering new effects of old drugs, it is feasible to use buformin as an anticancer drug in clinical application. This will provide new ideas for clinical treatment.

Indexed as

buformincell cycle arrestCervical cancerDNA damageradiosensitivity

Identifiers

PMID32459508
PMCPMC6327368
OpenAlexW2909815242

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.