Evidence map›Paper›PMID 32459417›Full record

ReviewObstetrics and gynecology2020

Ovarian Cancer After Prophylactic Salpingectomy in a Patient With Germline BRCA1 Mutation.

Nicole Lugo Santiago, Evan Smith, Mary Cox, Carrie S Wan, Nana E Tchabo, Ibraheem Awowole, Vance Broach, Dennis S Chi

Erratum issuedOpen access · greenAbstract readCase ReportsReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Obstetrics and gynecology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 10 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Nicole Lugo SantiagoGynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York; Atlantic Health System, Morristown, New Jersey; Obafemi Awolowo University, Ile-Ife, Nigeria; and the Department of Obstetrics and Gynecology, Weill Cornell Medical College, New York, New York.
Evan Smith
Mary Cox
Carrie S Wan
Nana E Tchabo
Ibraheem Awowole
Vance Broach
Dennis S Chi
Memorial Sloan Kettering Cancer Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

backgroundWomen with germline BRCA1 or BRCA2 mutations have a lifetime risk of ovarian cancer of up to 46%. Opportunistic salpingectomy has been advocated as a risk-reducing strategy owing to increasing recognition of tubal origin, yet evidence of efficacy in this high-risk population is limited. CASE: This is the case of a woman with a BRCA1 mutation who underwent prophylactic mastectomy and bilateral salpingectomy with ovarian retention before the age of 40 years. She did not undergo oophorectomy and subsequently developed stage IV high-grade serous ovarian cancer 4 years after her initial surgery.

conclusionMore research is needed to determine the role of prophylactic salpingectomy with delayed oophorectomy, optimal timing of completion oophorectomy, and the risks and benefits compared with up-front risk-reducing salpingo-oophorectomy.

Indexed as

Genes, BRCA1AdultCarcinoma, Ovarian EpithelialClinical Trials as TopicFemaleGenetic Predisposition to DiseaseGerm-Line MutationHumansMastectomyOvarian NeoplasmsOvariectomySalpingectomyTomography, X-Ray Computed

Identifiers

PMID32459417
PMCPMC7263355
OpenAlexW3020913118

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.