ReviewCartilage2021
Properties of Cartilage-Subchondral Bone Junctions: A Narrative Review with Specific Focus on the Growth Plate.
Review in Cartilage, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Article
- Design Strategies to Target Joint Resident Mesenchymal Stem Cells for Osteochondral Regeneration.Cells · 2026Review
- Quantitative traits of early-stage osteochondrosis lesions in porcine distal femurs are consistent with skeletal developmental age.JBMR plus · 2026Article
- Studying the formation of the zone of calcified cartilage in bovine cartilage explantsOsteoarthritis and cartilage open · 2026Article
- Chondrogenic Differentiation of Stem Cells for Cartilage Regeneration: Advances and Future Perspectives.Tissue engineering and regenerative medicine · 2026Review
- Effects of nutritional low phosphorus status caused by extremely low phosphorus diet during lactation and early childhood on endochondral ossification in offspring rats.Frontiers in nutrition · 2026Article
- BMSC-NFMC Model for Vascular Regulation and Interface Integration in Osteochondral Regeneration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Bioinspired Collagen/κ-Carrageenan 3D Matrix forACS biomaterials science & engineering · 2025Article
- Application of biodegradable implants in pediatric orthopedics: shifting from absorbable polymers to biodegradable metals.Bioactive materials · 2025Article
- Early alterations of the cartilage-subchondral bone unit in spontaneous osteoarthritis.Chinese medical journal · 2025Article
- 3D bioprinted scaffolds for osteochondral regeneration: advancements and applications.Materials today. Bio · 2025Review
- Osteochondral tissue engineering‑based subchondral bone plate repair (Review).Molecular medicine reports · 2025Review
- A phosphate glass reinforced composite acrylamide gradient scaffold for osteochondral interface regeneration.Biomaterials and biosystems · 2024Article
- Challenges and recent advances in engineering the osteochondral interface.Current opinion in biomedical engineering · 2024Article
- Drug-Loaded Bioscaffolds for Osteochondral Regeneration.Pharmaceutics · 2024Review
- Potential therapeutic strategies for osteoarthritis via CRISPR/Cas9 mediated gene editing.Reviews in endocrine & metabolic disorders · 2024Review
- Mesenchymal stem cell-derived exosomes as a promising cell-free therapy for knee osteoarthritis.Frontiers in bioengineering and biotechnology · 2024Review
- RUNX2 stabilization by long non-coding RNAs contributes to hypertrophic changes in human chondrocytes.International journal of biological sciences · 2023Article
- From mesenchymal niches to engineeredMaterials today. Bio · 2022Article
- Growing Pains: The Need for Engineered Platforms to Study Growth Plate Biology.Advanced healthcare materials · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe purpose of this narrative review is to summarize what is currently known about the structural, chemical, and mechanical properties of cartilage-bone interfaces, which provide tissue integrity across a bimaterial interface of 2 very different structural materials. Maintaining these mechanical interfaces is a key factor for normal bone growth and articular cartilage function and maintenance. MATERIALS AND
methodsA comprehensive search was conducted using Google Scholar and PubMed/Medline with a specific focus on the growth plate cartilage-subchondral bone interface. All original articles, reviews in journals, and book chapters were considered. Following a review of the overall structural and functional characteristics of the physis, the literature on histological studies of both articular and growth plate chondro-osseous junctions is briefly reviewed. Next the literature on biochemical properties of these interfaces is reviewed, specifically the literature on elemental analyses across the cartilage-subchondral bone junctions. The literature on biomechanical studies of these junctions at the articular and physeal interfaces is also reviewed and compared.
resultsUnlike the interface between articular cartilage and bone, growth plate cartilage has 2 chondro-osseous junctions. The reserve zone of the mature growth plate is intimately connected to a plate of subchondral bone on the epiphyseal side. This interface resembles that between the subchondral bone and articular cartilage, although much less is known about its makeup and formation.
conclusionThere is a notably paucity of information available on the structural and mechanical properties of reserve zone-subchondral epiphyseal bone interface. This review reveals that further studies are needed on the microstructural and mechanical properties of chondro-osseous junction with the reserve zone.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.