Evidence map›Paper›PMID 32458624›Full record

ArticleAsian Pacific journal of cancer prevention : APJCP2020

The Effect of (E)-1-(4'-aminophenyl)-3-phenylprop-2-en-1-one on MicroRNA-18a, Dicer1, and MMP-9 Expressions against DMBA-Induced Breast Cancer.

Ida Ayu Ika Wahyuniari, I Gusti Kamasan Nyoman Arijana, Ni Putu Sriwidyani, Hery Suwito, Sitarina Widyarini, Muhammad Ghufron, Mustofa Mustofa, Sofia Mubarika Haryana

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In one paragraph

Article in Asian Pacific journal of cancer prevention : APJCP, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 57% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Ida Ayu Ika WahyuniariDepartment of Histology, Faculty of Medicine, Udayana University, Bali, Indonesia.ORCID 0000-0003-3141-6247
I Gusti Kamasan Nyoman ArijanaDepartment of Histology, Faculty of Medicine, Udayana University, Bali, Indonesia.
Ni Putu SriwidyaniDepartment of Anatomical Pathology, Faculty of Medicine, Udayana University, Bali, Indonesia.
Hery SuwitoDepartment of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya, Indonesia.
Sitarina WidyariniDepartment of Pathology, Faculty of Veterinary Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia.
Muhammad GhufronDepartment of Histology and Cell Biology,Universitas Gadjah Mada, Yogyakarta, Indonesia.
Mustofa MustofaDepartment of Pharmacology and Therapy, Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia.
Sofia Mubarika HaryanaDepartment of Histology and Cell Biology,Universitas Gadjah Mada, Yogyakarta, Indonesia.ORCID 0000-0001-7205-652X
Udayana University · IDUniversitas Gadjah Mada · IDAirlangga University · ID

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMost of breast cancer patients are estrogen receptor alpha-positive and have high resistance and side effect of chemotherapeutic drug. Therefore, discovering an effective anticancer agent is needed. This research explored the effect of (E)-1-(4'-aminophenyl)-3-phenylprop-2-en-1-one (APE) on miR-18a, Dicer1, and MMP-9 expressions.

methodsTwenty four female Sprague-Dawley rats were invetigated in this study. The rats were divided into 6 groups of 4. G1 was considered as normal rat. G2, G3, T1, T2, and T3 were given DMBA 20 mg/kgBW twice a week for 5 weeks to induce mammary cancer. After being affiliated with cancer, G2 was given vehicle and G3 was treated with tamoxifen. T1, T2, and T3 were treated with APE intraperitoneally everyday for 21 days at doses of 5, 15, and 45 mg/kgBW/day, respectively. Blood plasma was collected to measure miR-18a expression using qRT-PCR. Mammary tissues were also collected to determine Dicer1 and MMP-9 expressions by using  immunohistochemistry.

resultsThe results showed significant down-regulation of miR-18a relative expression and up-regulation of Dicer1 expression in G3 and T1 compared to G2 (P<0.05). MMP-9 expression has significant decrease in T1 compared to G2 (P<0.05).

conclusionAPE can decrease miR-18a and MMP-9 expressions and increase Dicer1 expression in rat mammary cancer. Therefore, this compound could be a candidate of novel anticancer.

Indexed as

9,10-Dimethyl-1,2-benzanthraceneAniline CompoundsAnimalsAntineoplastic AgentsApoptosisBiomarkers, TumorCarcinogensCell ProliferationChalconeDEAD-box RNA HelicasesFemaleGene Expression Regulation, NeoplasticMammary Neoplasms, ExperimentalMatrix Metalloproteinase 9MiceMicroRNAs9,10-Dimethyl-1,2-benzanthraceneAniline CompoundsAntineoplastic AgentsBiomarkers, TumorCarcinogensChalconeDEAD-box RNA HelicasesDicer1 protein, ratMatrix Metalloproteinase 9MicroRNAsPropiophenonesRibonuclease IIIchalconeDicermammary cancermiR-18aMMP-9

Identifiers

PMID32458624
PMCPMC7541864
OpenAlexW3032484564

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.