ArticleJournal of integrative plant biology2020
Induction of γ-aminobutyric acid plays a positive role to Arabidopsis resistance against Pseudomonas syringae.
Article in Journal of integrative plant biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 58 citations in OpenAlex.
- Interaction of 4-Aminobutyrate (GABA) with the Tricarboxylic Acid Cycle in Plants Under Salinity Stress.Plants (Basel, Switzerland) · 2026Review
- Evolutionary dynamics and transcriptional diversification of GAD gene family in plants: a pan-species perspective in silico analysis.BMC plant biology · 2025Article
- Identification of Key Regulators Mediating Gamma-Aminobutyric Acid (GABA) and Organic Acid Accumulation in Strawberry.Plants (Basel, Switzerland) · 2025Article
- Regulatory helix deletion in glutamate decarboxylase reduces GABA and enhances Agrobacterium-mediated transient expression in lettuce.Journal of plant research · 2025Article
- Genomic and functional analyses reveal Pseudomonas granadensis CT364 is a plant growth-promoting endophyte.BMC microbiology · 2025Article
- Metabolomic Profiling Identifies Key Metabolites and Defense Pathways inInternational journal of molecular sciences · 2025Article
- Reduced content of gamma-aminobutyric acid enhances resistance to bacterial wilt disease in tomato.Plant biotechnology journal · 2025Article
- Effect of Exogenous γ-Aminobutyric Acid (GABA) on the Growth, Photosynthetic Pigment, Antioxidant and GABA Metabolism ofPlants (Basel, Switzerland) · 2025Article
- The molecular pathways leading to GABA and lactic acid accumulation in florets of organic broccoli rabe (Horticulture research · 2025Article
- GABA does not regulate stomatal CO2 signalling in Arabidopsis.Journal of experimental botany · 2024Article
- Flagellin Induced GABA-shunt improves Drought stress tolerance in Brassica napus L.BMC plant biology · 2024Article
- β-Aminobutyric acid promotes stress tolerance, physiological adjustments, as well as broad epigenetic changes at DNA and RNA nucleobases in field elms (Ulmus minor).BMC plant biology · 2024Article
- The potassium transporter TaNHX2 interacts with TaGAD1 to promote drought tolerance via modulating stomatal aperture in wheat.Science advances · 2024Article
- Antivirulence effects of cell-free culture supernatant of endophytic bacteria against grapevine crown gall agent, Agrobacterium tumefaciens, and induction of defense responses in plantlets via intact bacterial cells.BMC plant biology · 2024Article
- Gamma-aminobutyric acid treatment promotes resistance againstFrontiers in plant science · 2024Article
- Non-proteinogenic amino acids mitigate oxidative stress and enhance the resistance of common bean plants againstFrontiers in plant science · 2024Article
- Genetic Mapping of Tolerance to Bacterial Stem Blight Caused byPlants (Basel, Switzerland) · 2023Article
- γ-Aminobutyric acid plays a key role in alleviating Glomerella leaf spot in apples.Molecular plant pathology · 2023Article
- OsWRKY28 positively regulates salinity tolerance by directly activating OsDREB1B expression in rice.Plant cell reports · 2023Article
- Genome-wide analyses of LATERAL ORGAN BOUNDARIES in cassava reveal the role of LBD47 in defence against bacterial blight.PloS one · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Gamma-aminobutyric acid (GABA) is an important metabolite which functions in plant growth, development, and stress responses. However, its role in plant defense and how it is regulated are largely unknown. Here, we report a detailed analysis of GABA induction during the resistance response to Pseudomonas syringae in Arabidopsis thaliana. While searching for the mechanism underlying the pathogen-responsive mitogen-activated protein kinase (MPK)3/MPK6 signaling cascade in plant immunity, we found that activation of MPK3/MPK6 greatly induced GABA biosynthesis, which is dependent on the glutamate decarboxylase genes GAD1 and GAD4. Inoculation with Pseudomonas syringae pv tomato DC3000 (Pst) and Pst-avrRpt2 expressing the avrRpt2 effector gene induced GAD1 and GAD4 gene expression and increased the levels of GABA. Genetic evidence revealed that GAD1, GAD2, and GAD4 play important roles in both GABA biosynthesis and plant resistance in response to Pst-avrRpt2 infection. The gad1/2/4 triple and gad1/2/4/5 quadruple mutants, in which the GABA levels were extremely low, were more susceptible to both Pst and Pst-avrRpt2. Functional loss of MPK3/MPK6, or their upstream MKK4/MKK5, or their downstream substrate WRKY33 suppressed the induction of GAD1 and GAD4 expression after Pst-avrRpt2 treatment. Our findings shed light on both the regulation and role of GABA in the plant immunity to a bacterial pathogen.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.