Evidence map›Paper›PMID 32458446›Full record

ArticleBritish journal of haematology2021

Venetoclax induces rapid elimination of NPM1 mutant measurable residual disease in combination with low-intensity chemotherapy in acute myeloid leukaemia.

Ing S Tiong, Richard Dillon, Adam Ivey, Tse-Chieh Teh, Phillip Nguyen, Nicholas Cummings, David C Taussig, Annie-Louise Latif, Nicola E Potter, Manohursingh Runglall and 6 more

Open access · hybridAbstract read
In one paragraph

Article in British journal of haematology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 1 pooled it
7.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 1 synthesis or guideline pooled it, 87 citations in OpenAlex.

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  18. Biomarkers of Response to Venetoclax Therapy in Acute Myeloid Leukemia.International journal of molecular sciences · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 7 institutions in 2 countries.

Ing S TiongAlfred Hospital and Monash University, Melbourne, Vic., Australia.ORCID 0000-0001-7417-4343
Richard DillonDepartment of Medical and Molecular Genetics, King's College, London, UK.ORCID 0000-0001-9333-5296
Adam IveyAlfred Hospital and Monash University, Melbourne, Vic., Australia.
Tse-Chieh TehAlfred Hospital and Monash University, Melbourne, Vic., Australia.
Phillip NguyenAlfred Hospital and Monash University, Melbourne, Vic., Australia.
Nicholas CummingsAlfred Hospital and Monash University, Melbourne, Vic., Australia.
David C TaussigDepartment of Haematology, Royal Marsden Hospital, London, UK.
Annie-Louise LatifNHS Greater Glasgow and Clyde, Glasgow, UK.
Nicola E PotterDepartment of Medical and Molecular Genetics, King's College, London, UK.
Manohursingh RunglallNIHR Comprehensive Biomedical Research Centre at Guy's and St Thomas' NHS Foundation Trust in partnership with King's College London and King's College Hospital, London, UK.
Nigel H RussellGuy's and St Thomas' Hospitals, London, UK.
Kavita RajGuy's and St Thomas' Hospitals, London, UK.
Anthony P SchwarerBox Hill Hospital, Melbourne, Vic., Australia.
Chun Yew FongDepartment of Clinical Haematology, Austin Health and Olivia Newton John Cancer Research Institute, Melbourne, Vic., Australia.
Andrew P GriggDepartment of Clinical Haematology, Austin Health and Olivia Newton John Cancer Research Institute, Melbourne, Vic., Australia.
Andrew H WeiAlfred Hospital and Monash University, Melbourne, Vic., Australia.
The Alfred Hospital · AUSt Thomas' Hospital · GBKing's College London · GBOlivia Newton-John Cancer Wellness & Research Centre · AUBox Hill Hospital · AUNHS Greater Glasgow and Clyde · GBRoyal Marsden Hospital · GB

Funding

Cancer Research UK 29806
6 · The paper itself

Abstract

Based on promising results in older adults with acute myeloid leukaemia (AML), we treated patients with NPM1

Indexed as

Leukemia, Myeloid, AcuteMutationAdultAgedAged, 80 and overBridged Bicyclo Compounds, HeterocyclicFemaleHumansMaleMiddle AgedNeoplasm ProteinsNeoplasm, ResidualNuclear ProteinsNucleophosminRetrospective StudiesSulfonamidesBridged Bicyclo Compounds, HeterocyclicNeoplasm ProteinsNPM1 protein, humanNuclear ProteinsNucleophosminSulfonamidesvenetoclaxAMLMRDNPM1venetoclax

Identifiers

PMID32458446
PMCPMC8048658
OpenAlexW3030923281

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.