Evidence map›Paper›PMID 32458400›Full record

ReviewJournal of cardiovascular translational research2020

Implications for Neuromodulation Therapy to Control Inflammation and Related Organ Dysfunction in COVID-19.

Marat Fudim, Yawar J Qadri, Kamrouz Ghadimi, David B MacLeod, Jeroen Molinger, Jonathan P Piccini, John Whittle, Paul E Wischmeyer, Manesh R Patel, Luis Ulloa

Registry-linked trialOpen access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of cardiovascular translational research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05918965 (Effects of Transcutaneous Electrical Neurostimulation on Female Patients With Long COVID - a Pilot Study), which is not on this map. Cited by 43 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 1 pooled it
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05918965 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Effects of Transcutaneous Electrical Neurostimulation on Female Patients With Long COVID - a Pilot Study

TypeinterventionalSponsorMedical University of ViennaRan2023 to 2025Enrolled45ConditionsVagus Nerve Diseases, Long COVID, Long Covid19, Post-COVID-19 SyndromeArmstranscutaneous electrical vagal neurostimulation
3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 1 synthesis or guideline pooled it, 80 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Marat FudimDepartment of Medicine, Division of Cardiology, Duke University, 2301 Erwin Road, Durham, NC, 27710, USA. marat.fudim@duke.edu.ORCID http://orcid.org/0000-0002-8671-7007
Yawar J QadriDepartment of Anesthesiology & Critical Care, Duke University, Durham, NC, USA.
Kamrouz GhadimiDepartment of Anesthesiology & Critical Care, Duke University, Durham, NC, USA.
David B MacLeodDepartment of Anesthesiology & Critical Care, Duke University, Durham, NC, USA.
Jeroen MolingerDepartment of Anesthesiology & Critical Care, Duke University, Durham, NC, USA.
Jonathan P PicciniDepartment of Medicine, Division of Cardiology, Duke University, 2301 Erwin Road, Durham, NC, 27710, USA.
John WhittleDepartment of Anesthesiology & Critical Care, Duke University, Durham, NC, USA.
Paul E WischmeyerDepartment of Anesthesiology & Critical Care, Duke University, Durham, NC, USA.
Manesh R PatelDepartment of Medicine, Division of Cardiology, Duke University, 2301 Erwin Road, Durham, NC, 27710, USA.
Luis UlloaCenter for Perioperative Organ Protection, Department of Anesthesiology, Duke University, Durham, NC, USA.
Duke University · US

Funding

INTEGRATED TRAINING IN ANESTHESIOLOGY RESEARCHT32GM008600 · NIGMS · DUKE UNIVERSITY · PI Miriam Treggiari · 1996 to 2026
$6.6M
6 · The paper itself

Abstract

COVID-19 is a syndrome that includes more than just isolated respiratory disease, as severe acute respiratory syndrome-coronavirus 2 (SARS-CoV2) also interacts with the cardiovascular, nervous, renal, and immune system at multiple levels, increasing morbidity in patients with underlying cardiometabolic conditions and inducing myocardial injury or dysfunction. Emerging evidence suggests that patients with the highest rate of morbidity and mortality following SARS-CoV2 infection have also developed a hyperinflammatory syndrome (also termed cytokine release syndrome). We lay out the potential contribution of a dysfunction in autonomic tone to the cytokine release syndrome and related multiorgan damage in COVID-19. We hypothesize that a cholinergic anti-inflammatory pathway could be targeted as a therapeutic avenue. Graphical Abstract .

Indexed as

Cholinergic FibersCOVID-19 Drug TreatmentVagus Nerve StimulationAnimalsCOVID-19Cytokine Release SyndromeHost-Pathogen InteractionsHumansInflammationSARS-CoV-2Treatment OutcomeACE2COVID-19SARS-CoV2VagusVagus nerve stimulation

Identifiers

PMID32458400
PMCPMC7250255
OpenAlexW3032519486

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.