Evidence map›Paper›PMID 32458388›Full record

ArticleMolecular neurobiology2020

The Effect of Short-Term Physical Activity on the Oxidative Stress in Rats with Different Stress Resistance Profiles in Cerebral Hypoperfusion.

Vladimir V Chrishtop, Irina K Tomilova, Tatiana A Rumyantseva, Elizaveta V Mikhaylenko, Marco F Avila-Rodriguez, Liudmila M Mikhaleva, Vladimir N Nikolenko, Siva G Somasundaram, Cecil E Kirkland, Sergey O Bachurin and 1 more

Abstract read
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Article in Molecular neurobiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 3 countries.

Vladimir V ChrishtopCentral Research Laboratory, Ivanovo State Medical Academy, Avenue Sheremetyevsky 8, Ivanovo, Russian Federation, 153012.ORCID https://orcid.org/0000-0002-9267-5800
Irina K TomilovaDepartment of Biochemistry, Ivanovo State Medical Academy, Avenue Sheremetyevsky 8, Ivanovo, Russian Federation, 153012.ORCID https://orcid.org/0000-0002-3692-4884
Tatiana A RumyantsevaDepartment of Human Anatomy, Yaroslavl State Medical University, Street Revolutsionnaya 5, Yaroslavl, Russian Federation, 150000.ORCID https://orcid.org/0000-0002-8035-4065
Elizaveta V MikhaylenkoI. M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), 8/2 Trubetskaya Str., Moscow, Russia, 119991.ORCID https://orcid.org/0000-0002-6175-8179
Marco F Avila-RodriguezFaculty of Health Sciences, Department of Clinic Sciences, University of Tolima, Barrio Santa Helena, Ibagué, 730006, Colombia.
Liudmila M MikhalevaResearch Institute of Human Morphology, 3 Tsyurupy Street, Moscow, Russian Federation, 117418.
Vladimir N NikolenkoI. M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), 8/2 Trubetskaya Str., Moscow, Russia, 119991.
Siva G SomasundaramDepartment of Biological Sciences, Salem University, Salem, WV, 26426, USA.
Cecil E KirklandDepartment of Biological Sciences, Salem University, Salem, WV, 26426, USA.
Sergey O BachurinInstitute of Physiologically Active Compounds of Russian Academy of Sciences, 1 Severny pr., Chernogolovka, Moscow Region, Russia, 142432.
Gjumrakch AlievI. M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), 8/2 Trubetskaya Str., Moscow, Russia, 119991. aliev03@gmail.com.ORCID https://orcid.org/0000-0001-7373-3182
Sechenov University · RUIvanovo State Medical Academy · RUSalem University · USInstitute of Physiologically Active Compounds · RUResearch Institute of Human Morphology · RUUniversity of Tolima · COYaroslavl State Medical Academy · RU

Funding

IPAC RAS 0090-2019-0005IPAC RAS State Targets Project , Russian Federation 0090-2019-0005Science and Technology Project of State Grid (CN) 0090-2019-0005Sechenov University 5-100Sechenov University, Moscow, Russia 5-100
6 · The paper itself

Abstract

Oxidative stress associated with chronic cerebral hypoperfusion is one of the fundamental factors leading to neurodegenerative diseases. To prevent oxidative stress, physical activity is effective. Physical exercise enables development of rehabilitation techniques that can progressively increase patients' stress resistance. We determined the oxidative stress dynamics in experimental hypoperfusion and modeled rehabilitation measures, comparing sex and stress resistance levels. The experiment was performed on 240 Wistar rats of both sexes over a period of 90 days. Based on behavioral test results obtained using the open field test, the rats were divided into active animals with predicted higher stress resistance (HSR) and passive animals with predicted lower stress resistance (LSR). TBA (thiobarbituric acid) plasma concentration of the active products (malondialdehyde-MDA), blood plasma (NO-X) concentration, and L-citrulline (LC) concentration were determined spectrophotometrically at the corresponding wave length (nm). The intensity of oxidative stress was evaluated using the chemoluminscent method to determine the blood plasma antioxidant activity on the BCL-07 biochemoluminometer. This study revealed two stages of oxidative stress: a less pronounced phase covering the first days after surgery and a main one, which starts from the month after the operation to 3 months. Female sex and a high initial level of stress resistance reduced the severity of oxidative stress. Physical activity commencing a week after the surgery resulted in "reloading" the adaptive mechanisms and slowed the onset of the main stage, leading to a decrease in the free-radical process in all studied subgroups and the greater blood plasma (NO)-X decrease in the male animals. Future neuropharmacological intervention most likely will be able to determine the pathophysiology mechanism of chronic brain hypoperfusion and potentially extending adaptive responses.

Indexed as

AnimalsBrainBrain IschemiaFemaleMaleMalondialdehydeMaze LearningOxidative StressPhysical Conditioning, AnimalRats, WistarSex FactorsStress, PsychologicalThiobarbituratesMalondialdehydeThiobarbituratesthiobarbituric acidCerebral hypoperfusionFree-radical processesLearning abilityNeurodegenerative diseasesPhysical exertionThe level of stress tolerance

Identifiers

PMID32458388
OpenAlexW3029315599

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.