ArticleSleep & breathing = Schlaf & Atmung2021
Impact of low arousal threshold on treatment of obstructive sleep apnea in patients with post-traumatic stress disorder.
Article in Sleep & breathing = Schlaf & Atmung, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
- Physiological Traits and Adherence to Sleep Apnea Therapy in Individuals with Coronary Artery Disease.American journal of respiratory and critical care medicine · 2021Trial
- Comorbid Insomnia and Sleep Apnea Mechanistic Convergence, Phenotypic Heterogeneity, and Clinical Implications.Current sleep medicine reports · 2026Article
- Obstructive Sleep Apnea Syndrome and Ischemic Stroke: Investigating Inflammatory Mechanisms.Nature and science of sleep · 2026Review
- Article
- The effect of the arousal threshold on sleep bruxism intensity in coexisting sleep apnea and sleep bruxism: a polysomnographic study.Scientific reports · 2025Observational
- Determinants of treatment response to cognitive behavioral therapy in veterans presenting with comorbid insomnia and sleep apnea.Sleep & breathing = Schlaf & Atmung · 2025Article
- Chronic Obstructive Pulmonary Disease and Obstructive Sleep Apnea Coexistence: From Pathophysiology to Clinical Complications.International journal of chronic obstructive pulmonary disease · 2025Review
- From trenches to technology: a narrative review of sleep medicine in the military.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024Review
- The Present and Future of the Clinical Use of Physiological Traits for the Treatment of Patients with OSA: A Narrative Review.Journal of clinical medicine · 2024Review
- The effect of obstructive sleep apnea severity on PTSD symptoms during the course of esketamine treatment: a retrospective clinical study.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2023Article
- Respiratory arousal threshold among patients with isolated sleep apnea and with comorbid insomnia (COMISA).Scientific reports · 2023Article
- Examining the bidirectional relationship between posttraumatic stress disorder symptom clusters and PAP adherence.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2023Article
- Diagnostic performance of screening tools for the detection of obstructive sleep apnea in people living with HIV.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022Article
- Estimated respiratory arousal threshold in patients with rapid eye movement obstructive sleep apnea.Sleep & breathing = Schlaf & Atmung · 2022Observational
- A Narrative Review of the Association between Post-Traumatic Stress Disorder and Obstructive Sleep Apnea.Journal of clinical medicine · 2022Review
- STOP-BANG screener vs objective obstructive sleep apnea testing among younger veterans with PTSD and insomnia: STOP-BANG does not sufficiently detect risk.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022Article
- Understanding Sleep Apnea Physiology: A Potential Path to Improving Positive Airway Pressure Effectiveness.American journal of respiratory and critical care medicine · 2021Article
- Clinical characteristics of Asian patients with sleep apnea with low arousal threshold and sleep structure change with continuous positive airway pressure.Sleep & breathing = Schlaf & Atmung · 2021Article
- Comorbid sleep apnea, post-traumatic stress disorder, and insomnia: underlying mechanisms and treatment implications-a commentary on El Solh et al.'s Impact of low arousal threshold on treatment of obstructive sleep apnea in patients with post-traumatic stress disorder.Sleep & breathing = Schlaf & Atmung · 2021Article
- Low Arousal Threshold: A Potential Bridge Between OSA and Periodic Limb Movements of Sleep.Nature and science of sleep · 2021Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
purposeWe sought to determine the prevalence of low arousal threshold (LAT) in veterans with post-traumatic stress disorder (PTSD) and whether or not LAT is associated with decreased use of continuous positive airway pressure (CPAP).
methodsWe conducted a retrospective study of all veterans with documented PTSD who had an apnea hypopnea index > 5/h over a 27-month period. Demographic, clinical characteristics, and CPAP usage were extracted from the medical records. A multivariate analysis was conducted to assess predictors of CPAP use at 3 months in patients with LAT after adjusting for severity of PTSD.
resultsLAT was identified in 55% of 119 patients with PTSD and newly diagnosed OSA. LAT was associated with younger age (odds ratio [OR] 0.91; 95% confidence interval [CI] 0.86-0.95), lower BMI (OR 0.82; 95% CI 0.73-0.91), presence of insomnia (OR 1.34; 95% CI 1.19-1.81), and use of antidepressant (OR 1.14; 95% CI 1.09-2.01). PTSD severity, REM rebound, and the presence of baseline comorbid insomnia were each associated with CPAP use at 3 months. Neither daytime sleepiness, body mass index (BMI), nor LAT endotype was correlated with CPAP utilization. Insomnia was the only factor associated with decreased CPAP use in patients with PTSD and LAT (P = 0.04).
conclusionThe LAT endotype is common among veterans with PTSD. An improved understanding of how insomnia in this population affects CPAP utilization would be instrumental in designing targeted therapy to improve sleep quality.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.