Evidence map›Paper›PMID 32458371›Full record

ReviewBiophysical reviews2020

Recent progress and current opinions in Brillouin microscopy for life science applications.

Giuseppe Antonacci, Timon Beck, Alberto Bilenca, Jürgen Czarske, Kareem Elsayad, Jochen Guck, Kyoohyun Kim, Benedikt Krug, Francesca Palombo, Robert Prevedel and 1 more

Abstract readReview
In one paragraph

Review in Biophysical reviews, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. The mechanical properties ofScience advances · 2026
    Article
  6. Article
  7. Review
  8. Brillouin microscopy in cancer research: a review.Journal of biomedical optics · 2025
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Giuseppe AntonacciPhotonics Research Group, INTEC, Ghent University-imec, 9052, Ghent, Belgium.
Timon BeckBiotechnology Center, TU Dresden, Dresden, Germany.
Alberto BilencaBiomedical Engineering Department, Ben-Gurion University of the Negev, Beersheba, Israel.
Jürgen CzarskeLaboratory of Measurement and Sensor System Technique, TU Dresden, Dresden, Germany.
Kareem ElsayadAdvanced Microscopy, Vienna Biocenter Core Facilities (VBCF), Vienna, Austria. kareem.elsayad@vbcf.ac.at.
Jochen GuckBiotechnology Center, TU Dresden, Dresden, Germany.
Kyoohyun KimBiotechnology Center, TU Dresden, Dresden, Germany.
Benedikt KrugLaboratory of Measurement and Sensor System Technique, TU Dresden, Dresden, Germany.
Francesca PalomboSchool of Physics and Astronomy, University of Exeter, Exeter, UK.
Robert PrevedelCell Biology and Biophysics Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany. prevedel@embl.de.ORCID http://orcid.org/0000-0003-3366-4703
Giuliano ScarcelliFischell Department of Bioengineering, University of Maryland, College Park, MD, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Many important biological functions and processes are reflected in cell and tissue mechanical properties such as elasticity and viscosity. However, current techniques used for measuring these properties have major limitations, such as that they can often not measure inside intact cells and/or require physical contact-which cells can react to and change. Brillouin light scattering offers the ability to measure mechanical properties in a non-contact and label-free manner inside of objects with high spatial resolution using light, and hence has emerged as an attractive method during the past decade. This new approach, coined "Brillouin microscopy," which integrates highly interdisciplinary concepts from physics, engineering, and mechanobiology, has led to a vibrant new community that has organized itself via a European funded (COST Action) network. Here we share our current assessment and opinion of the field, as emerged from a recent dedicated workshop. In particular, we discuss the prospects towards improved and more bio-compatible instrumentation, novel strategies to infer more accurate and quantitative mechanical measurements, as well as our current view on the biomechanical interpretation of the Brillouin spectra.

Indexed as

BiomechanicsBrillouin microscopyOptical elastography

Identifiers

PMID32458371
PMCPMC7311586

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.