SynthesisNeurosurgical review2021
Safety and effectiveness of endoscopic endonasal intracranial aneurysm clipping: a systematic review.
Synthesis in Neurosurgical review, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Anatomic feasibility of endoscopic endonasal intracranial aneurysm clipping: a systematic review of anatomical studies.Neurosurgical review · 2021Pooled it
- Towards Realistic 3D-Printed Phantoms for Aneurysm Clipping: Mechanical Characterisation of Basilar Arteries.Bioengineering (Basel, Switzerland) · 2025Article
- Combined Transcranial and Endonasal Approach for Clipping of a Partially Thrombosed Giant Aneurysm of the Lower Basilar Artery.NMC case report journal · 2025Article
- Effects of Dexmedetomidine on Cognitive Function, Oxidative Stress and Brain Protection in Patients Undergoing Craniocerebral Surgery.Actas espanolas de psiquiatria · 2024Article
- Surgical Clipping of Intracranial Aneurysms Using a Transcranial Neuroendoscopic Approach.Brain sciences · 2023Article
- Craniopharyngioma resection and aneurysm clipping performed simultaneously by pure endoscopic endonasal approach: A case report and literature review.Oncology letters · 2022Article
- Management of Coincident Pituitary Macroadenoma and Cavernous Carotid Aneurysm: A Systematic Literature Review.Journal of neurological surgery reports · 2021Article
- Modern endoscopic skull base neurosurgery.Journal of neuro-oncology · 2021Review
- Transcranial fully endoscopic clipping techniques for ruptured aneurysms: an initial experience from a single center.Frontiers in neurologyArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Once considered far-fetched, endoscopic endonasal clipping (EEC) has been reported as a feasible alternative route for treating intracranial aneurysms located in the midline. Appropriately, debates regarding EEC applicability have arisen amongst the neurosurgical community. We aim to define the safety, effectiveness, and current state-of-art in the use of EEC for intracranial aneurysms. Two databases (PubMed, Cochrane) were queried for intracranial aneurysms that underwent EEC between inception and 2019. Literature review was performed according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. Data regarding clinical presentation, radiological imaging, and outcome were extracted and analyzed from selected publications. Nine studies with 27 patients (8 males, 19 females), harboring 35 aneurysms (9 ruptured, 26 nonruptured), met the predetermined inclusion criteria. Patient age range is from 34 to 70 (median = 50) years old. Four aneurysms were considered not suitable for EEC during the procedure, and two aneurysms required additional treatment, leading to an overall treatment success (obliteration) rate of 86%. Complications occurred in 7 patients (26%), including CSF leakage in 5 patients (18%) and ischemic complications in 4 (15%). Among the cases reported, complications occurred more frequently in posterior circulation aneurysms in comparison with anterior circulation aneurysms (62.5 vs 10.5%). Ischemic complications occurred in 4 out of 8 posterior circulation aneurysms. Although feasible, EEC is associated with a significant risk of complications, with rates identified that are significantly higher than established open clipping or endovascular management. The current data suggest that transcranial clipping and endovascular occlusion are still the primary indication for treating intracranial aneurysms.
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Registered trials
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