Evidence map›Paper›PMID 32458156›Full record

ArticleEuropean journal of applied physiology2020

MitoQ and CoQ10 supplementation mildly suppresses skeletal muscle mitochondrial hydrogen peroxide levels without impacting mitochondrial function in middle-aged men.

Toan Pham, Caitlin L MacRae, Sophie C Broome, Randall F D'souza, Ravi Narang, Hsiang W Wang, Trevor A Mori, Anthony J R Hickey, Cameron J Mitchell, Troy L Merry

Abstract read
PubMed Publisher
In one paragraph

Article in European journal of applied physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 3 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 3 syntheses or guidelines pooled it, 49 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Coenzyme QNutrients · 2022
    Pooled it
  4. Trial
  5. Trial
  6. Trial
  7. Trial
  8. Trial
  9. Trial
  10. Trial
  11. Review
  12. Coenzyme QMetabolic brain disease · 2026
    Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

Toan PhamDiscipline of Nutrition, School of Medical Sciences, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag, 92019, Auckland, New Zealand.
Caitlin L MacRaeDiscipline of Nutrition, School of Medical Sciences, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag, 92019, Auckland, New Zealand.
Sophie C BroomeDiscipline of Nutrition, School of Medical Sciences, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag, 92019, Auckland, New Zealand.
Randall F D'souzaDiscipline of Nutrition, School of Medical Sciences, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag, 92019, Auckland, New Zealand.
Ravi NarangSchool of Medicine, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand.
Hsiang W WangDepartment of Surgery, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand.
Trevor A MoriMedical School, Royal Perth Hospital Unit, University of Western Australia, Perth, Australia.
Anthony J R HickeySchool of Biological Sciences, Faculty of Science, The University of Auckland, Auckland, New Zealand.
Cameron J MitchellSchool of Kinesiology, University of British Columbia, Vancouver, Canada.
Troy L MerryDiscipline of Nutrition, School of Medical Sciences, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag, 92019, Auckland, New Zealand. t.merry@auckland.ac.nz.ORCID http://orcid.org/0000-0001-8699-500X
University of Auckland · NZThe University of Western Australia · AUUniversity of British Columbia · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeExcess production of reactive oxygen species (ROS) from the mitochondria can promote mitochondrial dysfunction and has been implicated in the development of a range of chronic diseases. As such there is interest in whether mitochondrial-targeted antioxidant supplementation can attenuate mitochondrial-associated oxidative stress. We investigated the effect of MitoQ and CoQ10 supplementation on oxidative stress and skeletal muscle mitochondrial ROS levels and function in healthy middle-aged men.

methodsSkeletal muscle and blood samples were collected from twenty men (50 ± 1 y) before and following six weeks of daily supplementation with MitoQ (20 mg) or CoQ10 (200 mg). High-resolution respirometry was used to determine mitochondrial respiration and H

resultsBoth MitoQ and CoQ10 supplementation suppressed mitochondrial net H

conclusionOur results suggest that neither MitoQ and CoQ10 supplements impact mitochondrial function, but both can mildly suppress mitochondrial ROS levels in healthy middle-aged men, with some indication that MitoQ may be more effective than CoQ10.

Indexed as

AdultAntioxidantsDietary SupplementsHumansHydrogen PeroxideMaleMiddle AgedMitochondriaMuscle, SkeletalOxidative StressReactive Oxygen SpeciesUbiquinoneAntioxidantscoenzyme Q10Hydrogen PeroxideReactive Oxygen SpeciesUbiquinoneAntioxidantMitochondriaMuscleOxidative stressROS

Identifiers

PMID32458156
OpenAlexW3031499810

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.