Evidence map›Paper›PMID 32458102›Full record

ArticleJournal of assisted reproduction and genetics2020

IUI and uterine lavage of in vivo-produced blastocysts for PGT purposes: is it a technically and ethically reasonable perspective? Is it actually needed?

Lucia De Santis, Danilo Cimadomo, Antonio Capalbo, Cinzia Di Pietro, Daniela Zuccarello, Attilio Anastasi, Emanuele Licata, Catello Scarica, Laura Sosa Fernandez, Francesca Gioia Klinger and 1 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of assisted reproduction and genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. When pregnancy is a research risk.Journal of assisted reproduction and genetics · 2020
    Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 8 institutions in 1 country.

Lucia De SantisDepartment of Obstetrics & Gynecology, IVF Unit, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy.
Danilo CimadomoGENERA Center for Reproductive Medicine, Clinica Valle Giulia, Rome, Italy. cimadomo@generaroma.it.ORCID 0000-0002-5390-9221
Antonio CapalboIgenomix, Marostica, Italy.
Cinzia Di PietroDAHFMO, Unit of Histology and Medical Embryology, Sapienza, University of Rome, Rome, Italy.
Daniela ZuccarelloUnit of Clinical Genetics and Epidemiology, Department of Lab Medicine, University Hospital of Padova, Padova, Italy.
Attilio AnastasiPhysiopathology of Human Reproduction Center, Hospital "del Delta", Lagosanto, Italy.
Emanuele LicataPhysiopathology of Reproduction and Andrology Unit, Sandro Pertini Hospital, Rome, Italy.
Catello ScaricaCasa di Cura Villa Salaria in partnership with Institut Marques, Reproductive Medicine, Rome, Italy.
Laura Sosa FernandezEmbryos Fertility Center, Battipaglia, Italy.
Francesca Gioia KlingerDepartment of Biomedicine and Prevention, Section of Histology and Embryology, University of Rome "Tor Vergata", Rome, Italy.
Italian Society of Embryology, Reproduction and Research (SIERR)
Clinica Valle Giulia · ITOspedale Sandro Pertini · ITPrysmian Group (Italy) · ITSapienza University of Rome · ITUniversity of Catania · ITUniversity of Padua · ITUniversity of Rome Tor Vergata · ITVita-Salute San Raffaele University · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A recent study by Munné et al. portrayed a protocol to retrieve in vivo produced blastocysts after IUI and uterine lavage for preimplantation genetic testing (PGT) purposes. The authors claimed this protocol might represent a reasonable future perspective for patients who do not want to undergo IVF, but still want to be informed about their embryos' genetic/chromosomal defects. Although the intent of making PGT available also to patients who cannot or do not need to undergo IVF is respectable, the value of this study is undermined by severe technical and ethical issues. Munné and colleagues' paper was discussed within the executive committee (i.e., president and vice-president of the society, director and vice-director of the scientific committee, secretariat, and counselors), the special interest group in reproductive genetics, the scientific committee, and the collegio dei probiviri of the Italian Society of Embryology, Reproduction and Research (SIERR). The points raised from this discussion are summarized in this opinion paper.

Indexed as

Preimplantation DiagnosisBlastocystFemaleGenetic TestingHumansInsemination, ArtificialPregnancyTherapeutic IrrigationBlastocystEthicsPGTPreimplantation developmentUterine lavage

Identifiers

PMID32458102
PMCPMC7376991
OpenAlexW3031544112

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.