Evidence map›Paper›PMID 32458060›Full record

SynthesisEuropean journal of pediatrics2020

Early versus late fortification of breast milk in preterm infants: a systematic review and meta-analysis.

Sriparna Basu, Jaya Upadhyay, Poonam Singh, Manish Kumar

Registry-linked trialAbstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in European journal of pediatrics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05251441 (The Effect of Time to Start Breast Milk Fortifiers on Neonatal Outcomes in Very Low Birth Weight Premature Infants.), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05251441 naunknown statusnot on this mapstarted 2021, after this paper: background citation

The Effect of Time to Start Breast Milk Fortifiers on Neonatal Outcomes in Very Low Birth Weight Premature Infants.

TypeinterventionalSponsorAnkara City Hospital BilkentRan2021 to 2022Enrolled160ConditionsBreast Milk Fortifier Supplements, PrematureArmsBreast Milk Fortifier supplements
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 15 citations in OpenAlex.

  1. Observational
  2. Review
  3. Maternal, neonatal, and nutritional risk factors for medical and surgical necrotizing enterocolitis.Journal of perinatology : official journal of the California Perinatal Association · 2024
    Article
  4. Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Sriparna BasuDepartment of Neonatology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, 249203, India. drsriparnabasu@rediffmail.com.ORCID http://orcid.org/0000-0001-5048-4849
Jaya UpadhyayDepartment of Neonatology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, 249203, India.
Poonam SinghDepartment of Neonatology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, 249203, India.
Manish KumarDepartment of Pediatrics, All India Institute of Medical Sciences, Gorakhpur, India.
All India Institute of Medical Sciences Rishikesh · INAll India Institute of Medical Sciences · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This systematic review and meta-analysis assessed the effects of early fortification (EF) versus late fortification (LF) of breast milk (BM) on growth of preterm infants. Randomized and quasi-randomized controlled trials (RCTs) dealing with the effects of EF versus LF on growth parameters, incidence of adverse events, and duration of hospital stay in preterm infants were included. Data were pooled using the RevMan 5.3 software. Quality of evidence for predefined outcomes was analyzed by GRADE. Available evidence (3 RCTs, 309 preterm infants) showed no statistically significant difference between EF and LF of BM for any of the growth parameters-weight (standardized mean difference (SMD) 0.13; 95% confidence interval (CI) - 0.09, 0.36); length (SMD 0.02; 95% CI - 0.20, 0.25); and head circumference (SMD - 0.10; 95% CI - 0.33, 0.12). Total parenteral nutrition days were similar. Duration of hospital stay was significantly higher with EF (MD 4.29; 95% CI 0.84, 7.75) with a trend of non-significant increase in feed intolerance and necrotizing enterocolitis (NEC).Conclusion: Very low quality evidence did not find any significant difference in growth parameters of preterm infants in association with EF or LF of BM. A significant increase in hospital stay and non-significant increase in feed intolerance and NEC were associated with EF.PROSPERO registration number: CRD42019139235What is Known:• Fortification of breast milk with essential macro- and micronutrients is necessary for optimization of nutrition in preterm infants.• There is no consensus regarding the breast milk feeding volume at which fortification should be initiated.What is New:• Very low quality evidence showed no significant difference between early and late fortification of breast milk on growth parameters of preterm infants.• Early fortification was associated with non-significant increase in feed intolerance and necrotizing enterocolitis and a significant increase in hospital stay.

Indexed as

Food, FortifiedMilk, HumanHumansInfant CareInfant, NewbornInfant, PrematureLength of StayMicronutrientsNutrientsOutcome Assessment, Health CareTime FactorsMicronutrientsNutrientsBreast milkEarlyGrowthHuman milk fortificationLateLow birth weight infantPreterm

Identifiers

PMID32458060
OpenAlexW3032244337

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.