Evidence map›Paper›PMID 32457908›Full record

ArticleFrontiers in cell and developmental biology2020

PCDH7 Inhibits the Formation of Homotypic Cell-in-Cell Structure.

Chenxi Wang, Ang Chen, Banzhan Ruan, Zubiao Niu, Yan Su, Hongquan Qin, You Zheng, Bo Zhang, Lihua Gao, Zhaolie Chen and 3 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.

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    Pooled it
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  13. Frontiers in genetics · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Chenxi WangSchool of Biology and Biological Engineering, South China University of Technology, Guangzhou, China.
Ang ChenLaboratory of Cell Engineering, Institute of Biotechnology, Beijing, China.
Banzhan RuanLaboratory of Cell Engineering, Institute of Biotechnology, Beijing, China.
Zubiao NiuLaboratory of Cell Engineering, Institute of Biotechnology, Beijing, China.
Yan SuLaboratory of Cell Engineering, Institute of Biotechnology, Beijing, China.
Hongquan QinLaboratory of Cell Engineering, Institute of Biotechnology, Beijing, China.
You ZhengLaboratory of Cell Engineering, Institute of Biotechnology, Beijing, China.
Bo ZhangDepartment of Oncology, Capital Medical University, Beijing, China.
Lihua GaoLaboratory of Cell Engineering, Institute of Biotechnology, Beijing, China.
Zhaolie ChenLaboratory of Cell Engineering, Institute of Biotechnology, Beijing, China.
Hongyan HuangDepartment of Oncology, Capital Medical University, Beijing, China.
Xiaoning WangSchool of Biology and Biological Engineering, South China University of Technology, Guangzhou, China.
Qiang SunLaboratory of Cell Engineering, Institute of Biotechnology, Beijing, China.
Capital Medical University · CNSouth China University of Technology · CNHainan Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Though homotypic cell-in-cell (hoCIC) structures are implicated in the development and progression of multiple human tumors, the molecular mechanisms underlying their formation remain poorly understood. We found that the expression of Protocadherin-7 (PCDH7), an integral membrane protein, was negatively associated with the formation of hoCIC structures. Overexpression of

Indexed as

actomyosinadherens junctionscell-in-cell structurePCDH7pMLC2

Identifiers

PMID32457908
PMCPMC7225324
OpenAlexW3021061361

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.