Evidence map›Paper›PMID 32457896›Full record

ArticleFrontiers in physics2020

Temporal stability of lipid-shelled microbubbles during acoustically-mediated blood-brain barrier opening.

Antonios N Pouliopoulos, Daniella A Jimenez, Alexander Frank, Alexander Robertson, Lin Zhang, Alina R Kline-Schoder, Vividha Bhaskar, Mitra Harpale, Elizabeth Caso, Nicholas Papapanou and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in physics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Assessment of Cavitation From DEFINITY and DEFINITY RT.Ultrasound in medicine & biology · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Acoustic Holograms for Bilateral Blood-Brain Barrier Opening in a Mouse Model.IEEE transactions on bio-medical engineering · 2022
    Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Antonios N PouliopoulosDepartment of Biomedical Engineering, Columbia University, New York City, New York 10032, USA.
Daniella A JimenezDepartment of Biomedical Engineering, Columbia University, New York City, New York 10032, USA.
Alexander FrankDepartment of Biomedical Engineering, Columbia University, New York City, New York 10032, USA.
Alexander RobertsonDepartment of Biomedical Engineering, Columbia University, New York City, New York 10032, USA.
Lin ZhangDepartment of Biomedical Engineering, Columbia University, New York City, New York 10032, USA.
Alina R Kline-SchoderDepartment of Biomedical Engineering, Columbia University, New York City, New York 10032, USA.
Vividha BhaskarDepartment of Biomedical Engineering, Columbia University, New York City, New York 10032, USA.
Mitra HarpaleDepartment of Biomedical Engineering, Columbia University, New York City, New York 10032, USA.
Elizabeth CasoDepartment of Biomedical Engineering, Columbia University, New York City, New York 10032, USA.
Nicholas PapapanouDepartment of Biomedical Engineering, Columbia University, New York City, New York 10032, USA.
Rachel AndersonDepartment of Biomedical Engineering, Columbia University, New York City, New York 10032, USA.
Rachel LiDepartment of Biomedical Engineering, Columbia University, New York City, New York 10032, USA.
Elisa E KonofagouDepartment of Biomedical Engineering, Columbia University, New York City, New York 10032, USA.

Funding

Assessment of Ultrsound-facilitated Neurotherapeutics in Alzheimer's DiseaseR01AG038961 · NIA · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI KONOFAGOU, ELISA E. · 2011 to 2020
$5.1M
Optimization of ultrasound-facilitated blood-brain barrier openingR01EB009041 · NIBIB · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI KONOFAGOU, ELISA E. · 2008 to 2017
$4.4M
A theranostic system for ultrasound-facilitated blood-brain barrier openingR01EB029338 · NIBIB · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI KONOFAGOU, ELISA E. · 2020 to 2023
$2.6M
NIA NIH HHS R01 AG038961NIBIB NIH HHS R01 EB009041NIBIB NIH HHS R01 EB029338
6 · The paper itself

Abstract

Non-invasive blood-brain barrier (BBB) opening using focused ultrasound (FUS) is being tested as a means to locally deliver drugs into the brain. Such FUS therapies require injection of preformed microbubbles, currently used as contrast agents in ultrasound imaging. Although their behavior during exposure to imaging sequences has been well described, our understanding of microbubble stability within a therapeutic field is still not complete. Here, we study the temporal stability of lipid-shelled microbubbles during therapeutic FUS exposure in two timescales: the short time scale (i.e., μs of low-frequency ultrasound exposure) and the long time scale (i.e., days post-activation). We first simulated the microbubble response to low-frequency sonication, and found a strong correlation between viscosity and fragmentation pressure. Activated microbubbles had a concentration decay constant of 0.02 d

Indexed as

blood-brain barriercontrast agentsfocused ultrasoundmicrobubblespassive cavitation detectiontemporal stability

Identifiers

PMID32457896
PMCPMC7250395

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.