Evidence map›Paper›PMID 32457890›Full record

ArticleFrontiers in bioengineering and biotechnology2020

Trapping and Manipulation of Single Cells in Crowded Environments.

Qian Zhao, Hao-Wei Wang, Pan-Pan Yu, Shu-He Zhang, Jin-Hua Zhou, Yin-Mei Li, Lei Gong

Abstract read
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Light force-powered cellular medical micromachines.Frontiers in bioengineering and biotechnology · 2026
    Review
  2. Review
  3. Article
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  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Non-Invasive Dynamic Reperfusion of MicrovesselsFrontiers in bioengineering and biotechnology · 2022
    Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Qian ZhaoDepartment of Optics and Optical Engineering, University of Science and Technology of China, Hefei, China.
Hao-Wei WangDepartment of Optics and Optical Engineering, University of Science and Technology of China, Hefei, China.
Pan-Pan YuDepartment of Optics and Optical Engineering, University of Science and Technology of China, Hefei, China.
Shu-He ZhangDepartment of Biomedical Engineering, Anhui Medical University, Hefei, China.
Jin-Hua ZhouDepartment of Biomedical Engineering, Anhui Medical University, Hefei, China.
Yin-Mei LiDepartment of Optics and Optical Engineering, University of Science and Technology of China, Hefei, China.
Lei GongDepartment of Optics and Optical Engineering, University of Science and Technology of China, Hefei, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Optical tweezers provide a powerful tool to trap and manipulate living cells, which is expected to help people gain physiological insights at single-cell level. However, trapping and manipulating single cells under crowded environments, such as blood vessels and lymph nodes, is still a challenging task. To overcome this issue, an annular beam formed by the far-field Bessel beam is introduced to serve as an optical shield to isolate the target cells from being disturbed. With this scheme, we successfully trapped and manipulated single blood cells in a crowded environment. Furthermore, we demonstrated manipulation of two lymphocytes ejected from a lymph node independently with dual-trap optical tweezers, which paves the way for exploring cell interactions under living conditions. Such technique might be helpful in the study of how natural killer cells response to virus-infected cells or cancer cells.

Indexed as

crowded environmentlymphocytesoptical forceoptical shieldoptical tweezers

Identifiers

PMID32457890
PMCPMC7227430

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.