Evidence map›Paper›PMID 32457742›Full record

ReviewFrontiers in immunology2020

B and T Cells Driving Multiple Sclerosis: Identity, Mechanisms and Potential Triggers.

Jamie van Langelaar, Liza Rijvers, Joost Smolders, Marvin M van Luijn

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 197 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
197citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

197 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
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  6. Review
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  8. Article
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  11. Association of epiretinal membranes with disability in people with multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2026
    Article
  12. Review
  13. Article
  14. Article
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  17. ODC1 restricts meningeal B cell age-associated-like phenotype and function in multiple sclerosis: A human and experimental study.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  18. Article
  19. Review
  20. Review

137 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jamie van LangelaarDepartment of Immunology, MS Center ErasMS, Erasmus MC, University Medical Center, Rotterdam, Netherlands.
Liza RijversDepartment of Immunology, MS Center ErasMS, Erasmus MC, University Medical Center, Rotterdam, Netherlands.
Joost SmoldersDepartment of Immunology, MS Center ErasMS, Erasmus MC, University Medical Center, Rotterdam, Netherlands.
Marvin M van LuijnDepartment of Immunology, MS Center ErasMS, Erasmus MC, University Medical Center, Rotterdam, Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Historically, multiple sclerosis (MS) has been viewed as being primarily driven by T cells. However, the effective use of anti-CD20 treatment now also reveals an important role for B cells in MS patients. The results from this treatment put forward T-cell activation rather than antibody production by B cells as a driving force behind MS. The main question of how their interaction provokes both B and T cells to infiltrate the CNS and cause local pathology remains to be answered. In this review, we highlight key pathogenic events involving B and T cells that most likely contribute to the pathogenesis of MS. These include (1) peripheral escape of B cells from T cell-mediated control, (2) interaction of pathogenic B and T cells in secondary lymph nodes, and (3) reactivation of B and T cells accumulating in the CNS. We will focus on the functional programs of CNS-infiltrating lymphocyte subsets in MS patients and discuss how these are defined by mechanisms such as antigen presentation, co-stimulation and cytokine production in the periphery. Furthermore, the potential impact of genetic variants and viral triggers on candidate subsets will be debated in the context of MS.

Indexed as

Lymphocyte ActivationAnimalsB-LymphocytesCentral Nervous SystemCytokinesGerminal CenterHumansMiceMultiple SclerosisT-LymphocytesCytokinesCD8+ T cellsEpstein-Barr virusgenetic riskgerminal centerIFN-γT-bet+ B cellsTh1/Th17transmigration

Identifiers

PMID32457742
PMCPMC7225320

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.