Evidence map›Paper›PMID 32457739›Full record

ArticleFrontiers in immunology2020

CD28 Signaling Drives Notch Ligand Expression on CD4 T Cells.

Ankita Mitra, Sudarvili Shanthalingam, Heather L Sherman, Khushboo Singh, Mine Canakci, Joe A Torres, Rebecca Lawlor, Yong Ran, Todd E Golde, Lucio Miele and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
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  6. Article
  7. Elevated Notch ligands in serum are associated with HIV/TB coinfection.Journal of clinical tuberculosis and other mycobacterial diseases · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Ankita MitraDepartment of Veterinary and Animal Sciences, University of Massachusetts Amherst, Amherst, MA, United States.
Sudarvili ShanthalingamDepartment of Veterinary and Animal Sciences, University of Massachusetts Amherst, Amherst, MA, United States.
Heather L ShermanDepartment of Veterinary and Animal Sciences, University of Massachusetts Amherst, Amherst, MA, United States.
Khushboo SinghDepartment of Chemistry, University of Massachusetts Amherst, Amherst, MA, United States.
Mine CanakciDepartment of Veterinary and Animal Sciences, University of Massachusetts Amherst, Amherst, MA, United States.
Joe A TorresDepartment of Veterinary and Animal Sciences, University of Massachusetts Amherst, Amherst, MA, United States.
Rebecca LawlorDepartment of Veterinary and Animal Sciences, University of Massachusetts Amherst, Amherst, MA, United States.
Yong RanCenter for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, FL, United States.
Todd E GoldeCenter for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, FL, United States.
Lucio MieleSchool of Medicine, Department of Genetics, LSU Health Sciences Center, New Orleans, LA, United States.
Sankaran ThayumanavanDepartment of Chemistry, University of Massachusetts Amherst, Amherst, MA, United States.
Lisa M MinterDepartment of Veterinary and Animal Sciences, University of Massachusetts Amherst, Amherst, MA, United States.
Barbara A OsborneDepartment of Veterinary and Animal Sciences, University of Massachusetts Amherst, Amherst, MA, United States.
University of Massachusetts Amherst · USUniversity of Florida · USLouisiana State University Health Sciences Center New Orleans · US

Funding

Tracking & Evaluation CoreU54GM104940 · NIGMS · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Peter Todd Katzmarzyk · 2012 to 2026
$69.1M
NIGMS NIH HHS U54 GM104940
6 · The paper itself

Abstract

Notch signaling provides an important cue in the mammalian developmental process. It is a key player in T cell development and function. Notch ligands such as Delta-like ligands (DLL) 1, 3, 4, and JAG1, 2 can impact Notch signaling positively or negatively, by

Indexed as

Adaptor Proteins, Signal TransducingAnimalsAntibodiesCalcium-Binding ProteinsCD28 AntigensCD3 ComplexCD4-Positive T-LymphocytesFemaleHEK293 CellsHumansJagged-1 ProteinLigandsLymphocyte ActivationMiceMice, Inbred C57BLMice, TransgenicAdaptor Proteins, Signal TransducingAntibodiesCalcium-Binding ProteinsCD28 AntigensCD3 ComplexCd3e protein, mouseDlk1 protein, mouseDLL4 protein, mouseJag1 protein, mouseJagged-1 ProteinLigandsNotch1 protein, mouseReceptor, Notch1CD28cisDLL1DLL4JAG1Notch1

Identifiers

PMID32457739
PMCPMC7221189
OpenAlexW3021744266

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.