Evidence map›Paper›PMID 32457736›Full record

ArticleFrontiers in immunology2020

ILC2 Lung-Homing in Cystic Fibrosis Patients: Functional Involvement of CCR6 and Impact on Respiratory Failure.

Anja Schulz-Kuhnt, Vicky Greif, Kai Hildner, Lisa Knipfer, Michael Döbrönti, Sabine Zirlik, Florian Fuchs, Raja Atreya, Sebastian Zundler, Rocío López-Posadas and 8 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 28 citations in OpenAlex.

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  14. The mechanism of gut-lung axis in pulmonary fibrosis.Frontiers in cellular and infection microbiology · 2024
    Review
  15. Elevated Proportions of Circulating CXCR5Journal of immunology research · 2024
    Article
  16. Heterogeneity of type 2 innate lymphoid cells.Nature reviews. Immunology · 2022
    Review
  17. Review
  18. Review
  19. Mucosal Immunity in Cystic Fibrosis.Journal of immunology (Baltimore, Md. : 1950) · 2021
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 1 institution in 1 country.

Anja Schulz-KuhntDepartment of Medicine 1, University Hospital of Erlangen, Erlangen, Germany.
Vicky GreifDepartment of Medicine 1, University Hospital of Erlangen, Erlangen, Germany.
Kai HildnerDepartment of Medicine 1, University Hospital of Erlangen, Erlangen, Germany.
Lisa KnipferDepartment of Medicine 1, University Hospital of Erlangen, Erlangen, Germany.
Michael DöbröntiDepartment of Medicine 1, University Hospital of Erlangen, Erlangen, Germany.
Sabine ZirlikDepartment of Medicine 1, University Hospital of Erlangen, Erlangen, Germany.
Florian FuchsDepartment of Medicine 1, University Hospital of Erlangen, Erlangen, Germany.
Raja AtreyaDepartment of Medicine 1, University Hospital of Erlangen, Erlangen, Germany.
Sebastian ZundlerDepartment of Medicine 1, University Hospital of Erlangen, Erlangen, Germany.
Rocío López-PosadasDepartment of Medicine 1, University Hospital of Erlangen, Erlangen, Germany.
Clemens NeufertDepartment of Medicine 1, University Hospital of Erlangen, Erlangen, Germany.
Andreas RammingDepartment of Medicine 3, University Hospital of Erlangen, Erlangen, Germany.
Alexander KieferDepartment of Pediatrics and Adolescent Medicine, University Hospital of Erlangen, Erlangen, Germany.
Anika GrüneboomDepartment of Medicine 3, University Hospital of Erlangen, Erlangen, Germany.
Erwin StrasserDepartment of Transfusion Medicine and Haemostaseology, University Hospital of Erlangen, Erlangen, Germany.
Stefan WirtzDepartment of Medicine 1, University Hospital of Erlangen, Erlangen, Germany.
Markus F NeurathDepartment of Medicine 1, University Hospital of Erlangen, Erlangen, Germany.
Imke AtreyaDepartment of Medicine 1, University Hospital of Erlangen, Erlangen, Germany.
Universitätsklinikum Erlangen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cystic fibrosis patients suffer from a progressive, often fatal lung disease, which is based on a complex interplay between chronic infections, locally accumulating immune cells and pulmonary tissue remodeling. Although group-2 innate lymphoid cells (ILC2s) act as crucial initiators of lung inflammation, our understanding of their involvement in the pathogenesis of cystic fibrosis remains incomplete. Here we report a marked decrease of circulating CCR6

Indexed as

Immunity, InnateLymphocyte ActivationAdolescentAdultAgedAnimalsArthritis, RheumatoidCell MovementChemokine CCL20Cystic FibrosisDisease Models, AnimalFemaleHumansInflammatory Bowel DiseasesLungLymphocytesCCL20 protein, humanCCR6 protein, humanChemokine CCL20Receptors, CCR6CCR6cystic fibrosisgroup-2 innate lymphoid cellstissue remodelingtype-VI collagen

Identifiers

PMID32457736
PMCPMC7221160
OpenAlexW3021672892

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.