Evidence map›Paper›PMID 32457666›Full record

ArticleFrontiers in psychiatry2020

Potential Locations for Noninvasive Brain Stimulation in Treating Autism Spectrum Disorders-A Functional Connectivity Study.

Yiting Huang, Binlong Zhang, Jin Cao, Siyi Yu, Georgia Wilson, Joel Park, Jian Kong

Open access · goldAbstract read
In one paragraph

Article in Frontiers in psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 4 pooled it
2.0field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 4 syntheses or guidelines pooled it, 31 citations in OpenAlex.

  1. Pooled it
  2. Comparative efficacy of different noninvasive brain stimulation protocols on upper-extremity motor function and activities of daily living after stroke: a systematic review and network meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
    Pooled it
  3. Pooled it
  4. Brain stimulation targets for chronic pain: Insights from meta-analysis, functional connectivity and literature review.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2024
    Pooled it
  5. Multisession tDCS combined with intrastimulation training improves emotion recognition in adolescents with autism spectrum disorder.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2024
    Trial
  6. Trial
  7. A meta-analysis of the effect of non-invasive neuromodulation techniques on improving cognitive function in patients with Alzheimer's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Review
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  15. Article
  16. The Role of Structure MRI in Diagnosing Autism.Diagnostics (Basel, Switzerland) · 2022
    Article
  17. Review
  18. Article
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  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Yiting HuangDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Binlong ZhangDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Jin CaoDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Siyi YuDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Georgia WilsonDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Joel ParkDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Jian KongDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Massachusetts General Hospital · USHarvard University · US

Funding

Neuromodulation of placebo and nocebo effectsR01AT008563 · NCCIH · MASSACHUSETTS GENERAL HOSPITAL · PI KONG, JIAN · 2015 to 2019
$3.9M
Modulation effects of imagined acupuncture and no touch placebo acupunctureR33AT009310 · NCCIH · MASSACHUSETTS GENERAL HOSPITAL · PI KONG, JIAN · 2018 to 2021
$2.7M
Enhancing acupuncture treatment effect through non-invasive neuromodulationR33AT009341 · NCCIH · MASSACHUSETTS GENERAL HOSPITAL · PI KONG, JIAN · 2019 to 2021
$2.5M
Treatment of chronic low back pain with transcutaneous auricular vagus nerve stimulationR34DA046635 · NIDA · MASSACHUSETTS GENERAL HOSPITAL · PI KONG, JIAN · 2019 to 2021
$766k
Neural dynamics of directly and indirectly conditioned placebo/nocebo effectR21AT008707 · NCCIH · MASSACHUSETTS GENERAL HOSPITAL · PI KONG, JIAN · 2016 to 2017
$479k
NCCIH NIH HHS R01 AT008563NCCIH NIH HHS R21 AT008707NCCIH NIH HHS R33 AT009310NCCIH NIH HHS R33 AT009341NIDA NIH HHS R34 DA046635
6 · The paper itself

Abstract

objectivesNoninvasive brain stimulation (NIBS) is an emerging tool for treating autism spectrum disorder (ASD). Exploring new stimulation targets may improve the efficacy of NIBS for ASD. MATERIALS AND

methodsWe first conducted a meta-analysis on 170 functional magnetic resonance imaging studies to identify ASD-associated brain regions. We then performed resting state functional connectivity analysis on 70 individuals with ASD to investigate brain surface regions correlated with these ASD-associated regions and identify potential NIBS targets for ASD.

resultsWe found that the medial prefrontal cortex, angular gyrus, dorsal lateral prefrontal cortex, inferior frontal gyrus, superior parietal lobe, postcentral gyrus, precentral gyrus, middle temporal gyrus, superior temporal sulcus, lateral occipital cortex, and supplementary motor area/paracentral gyrus are potential locations for NIBS in ASD.

conclusionOur findings may shed light on the development of new NIBS targets for ASD.

Indexed as

autism spectrum disordersfMRImeta-analysisnoninvasive brain stimulation

Identifiers

PMID32457666
PMCPMC7221195
OpenAlexW3023746168

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.