ReviewFrontiers in physiology2020
The Role of Peptide Hormones in Insect Lipid Metabolism.
Review in Frontiers in physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
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Who cites it
60 citing papers in PubMed, 152 citations in OpenAlex.
- Sex-biased expression of enteroendocrine cell-derived hormones contributes to higher fat storage ineLife · 2026Article
- tca-miR-3835-5p-ACPR-ACC neuroendocrine axis controls locomotor behavior via lipid metabolism in Tribolium castaneum.Pest management science · 2026Article
- Renaming the 'OS-D/CSP' Family (Part 2): '4-Cysteine Soluble Proteins' (4CSPs)-Intracellular Functions.Insects · 2026Review
- Multi-omics reveals an ecdysone-activated Eip75B-FABP signaling axis coordinating nutrient metabolism for development in Hermetia illucens.Journal of advanced research · 2026Article
- HvarAKR1B1-mediated tolerance in Hippodamia variegata: Deciphering the metabolic adaptation and fitness costs under prolonged starvation.Pest management science · 2026Article
- Threonine sulfation: a rare post translational modification in insect adipokinetic hormones.Scientific reports · 2026Article
- A Cold Stress-Activated Endocrine Sentinel Chemical Hormone Promotes Insect Survival via Mitochondrial Adaptations Through the Adipokinetic Hormone Receptor.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Insect Flight and Lipid Metabolism: Beyond the Classic Knowledge.Advances in experimental medicine and biology · 2026Review
- Lipid Metabolism in Relation to Calcium Homeostasis.Advances in experimental medicine and biology · 2026Review
- Lipid Metabolism in Diapause.Advances in experimental medicine and biology · 2026Review
- Serotonin drives fat storage via 5-HT7 signaling in Drosophila.Genes & genomics · 2026Article
- Lipids in Insect Reproduction: Where, How, and Why.Advances in experimental medicine and biology · 2026Review
- The inhibition mechanism ofFrontiers in microbiology · 2026Review
- Tachykinin-related peptide signalling is important for the immune response of the mealworm beetleFrontiers in immunology · 2026Article
- Endocrine Control of Lipid Metabolism.Advances in experimental medicine and biology · 2026Review
- Lipid Metabolism as a Target Site in Pest Control.Advances in experimental medicine and biology · 2026Review
- Lipid Metabolism in Relation to Carbohydrate Metabolism.Advances in experimental medicine and biology · 2026Review
- Expression and RNAi characterization of neuropeptides underlying developmental regulation in the Colorado potato beetle.Frontiers in insect science · 2026Article
- Insect neuropeptides as agents for pest control: potential and challenges.Biological research · 2025Review
- Oxygen-dependent regulation of serotonin receptoriScience · 2025Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lipids are the primary storage molecules and an essential source of energy in insects during reproduction, prolonged periods of flight, starvation, and diapause. The coordination center for insect lipid metabolism is the fat body, which is analogous to the vertebrate adipose tissue and liver. The fat body is primarily composed of adipocytes, which accumulate triacylglycerols in intracellular lipid droplets. Genomics and proteomics, together with functional analyses, such as RNA interference and CRISPR/Cas9-targeted genome editing, identified various genes involved in lipid metabolism and elucidated their functions. However, the endocrine control of insect lipid metabolism, in particular the roles of peptide hormones in lipogenesis and lipolysis are relatively less-known topics. In the current review, the neuropeptides that directly or indirectly affect insect lipid metabolism are introduced. The primary lipolytic and lipogenic peptide hormones are adipokinetic hormone and the brain insulin-like peptides (ILP2, ILP3, ILP5). Other neuropeptides, such as insulin-growth factor ILP6, neuropeptide F, allatostatin-A, corazonin, leucokinin, tachykinins and limostatin, might stimulate lipolysis, while diapause hormone-pheromone biosynthesis activating neuropeptide, short neuropeptide F, CCHamide-2, and the cytokines Unpaired 1 and Unpaired 2 might induce lipogenesis. Most of these peptides interact with one another, but mostly with insulin signaling, and therefore affect lipid metabolism indirectly. Peptide hormones are also involved in lipid metabolism during reproduction, flight, diapause, starvation, infections and immunity; these are also highlighted. The review concludes with a discussion of the potential of lipid metabolism-related peptide hormones in pest management.
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