ArticleFrontiers in physiology2020
A Comprehensive Engineering Analysis of Left Heart Dynamics After MitraClip in a Functional Mitral Regurgitation Patient.
Article in Frontiers in physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 38 citations in OpenAlex.
- A Physiologic Left Ventricle Flow Phantom for 4D Flow MRI Applications and CFD Verification.Annals of biomedical engineering · 2026Article
- Leaflet Lengths and Commissural Dimensions as the Primary Determinants of Orifice Area in Mitral Regurgitation: A Sobol Sensitivity Analysis.Bioengineering (Basel, Switzerland) · 2026Article
- Toward precision in simulation of paediatric mitral valve repair using patient-specific fluid-structure interaction modelling.European heart journal. Imaging methods and practice · 2026Article
- Effect of Transcatheter Edge-to-Edge Repair on Left Ventricular Flow Features.Cardiovascular engineering and technology · 2025Article
- Experimental Investigation of the Effect of a MitraClip on Left Ventricular Flow Dynamics.Annals of biomedical engineering · 2025Article
- Numerical validation of the applicability of the simplified ventricular model in the analysis of hemolysis in the mitral paravalvular leak.Frontiers in bioengineering and biotechnology · 2025Article
- Patient-Specific Quantitative In-Vivo Assessment of Human Mitral Valve Leaflet Strain Before and After MitraClip Repair.Cardiovascular engineering and technology · 2023Article
- Utilization of Engineering Advances for Detailed Biomechanical Characterization of the Mitral-Ventricular Relationship to Optimize Repair Strategies: A Comprehensive Review.Bioengineering (Basel, Switzerland) · 2023Review
- Machine learning used for simulation of MitraClip intervention: A proof-of-concept study.Frontiers in genetics · 2023Article
- Parametric analysis of transcatheter aortic valve replacement in transcatheter aortic valve replacement: evaluation of coronary flow obstruction.Frontiers in bioengineering and biotechnology · 2023Article
- Effects of MitraClip Therapy on Mitral Flow Patterns and Vortex Formation: An In Vitro Study.Annals of biomedical engineering · 2022Article
- Clinical Impact of Computational Heart Valve Models.Materials (Basel, Switzerland) · 2022Review
- A Simulation Study of the Effects of Number and Location of MitraClips on Mitral Regurgitation.JACC. Advances · 2022Article
- Invasive hemodynamics are equivocal for functional outcomes after MitraClip.Health science reports · 2022Article
- State-of-the-art intra-procedural imaging for the mitral and tricuspid PASCAL Repair System.European heart journal. Cardiovascular Imaging · 2022Review
- Computational Analysis of Flow Structures in Turbulent Ventricular Blood Flow Associated With Mitral Valve Intervention.Frontiers in physiology · 2022Article
- Effect of transcatheter edge-to-edge repair device position on diastolic hemodynamic parameters: An echocardiography-based simulation study.Frontiers in cardiovascular medicine · 2022Article
- Fluid-Structure Interaction Analyses of Biological Systems Using Smoothed-Particle Hydrodynamics.Biology · 2021Review
- In Vivo Image-Based 4D Modeling of Competent and Regurgitant Mitral Valve Dynamics.Experimental mechanics · 2021Article
- Mitral Valve Atlas for Artificial Intelligence Predictions of MitraClip Intervention Outcomes.Frontiers in cardiovascular medicine · 2021Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Percutaneous edge-to-edge mitral valve (MV) repair using MitraClip has been recently established as a treatment option for patients with heart failure and functional mitral regurgitation (MR), which significantly expands the number of patients that can be treated with this device. This study aimed to quantify the morphologic, hemodynamic and structural changes, and evaluate the biomechanical interaction between the MitraClip and the left heart (LH) complex of a heart failure patient with functional MR using a fluid-structure interaction (FSI) modeling framework. MitraClip implantation using lateral, central and double clip positions, as well as combined annuloplasty procedures were simulated in a patient-specific LH model that integrates detailed anatomic structures, incorporates age- and gender-matched non-linear elastic material properties, and accounts for mitral chordae tethering. Our results showed that antero-posterior distance, mitral annulus spherecity index, anatomic regurgitant orifice area, and anatomic opening orifice area decreased by up to 28, 39, 52, and 71%, respectively, when compared to the pre-clip model. MitraClip implantation immediately decreased the MR severity and improved the hemodynamic profile, but imposed a non-physiologic configuration and loading on the mitral apparatus, with anterior and posterior leaflet stress significantly increasing up to 210 and 145% during diastole, respectively. For this patient case, while implanting a combined central clip and ring resulted in the highest reduction in the regurgitant volume (46%), this configuration also led to mitral stenosis. Patient-specific computer simulations as used here can be a powerful tool to examine the complex device-host biomechanical interaction, and may be useful to guide device positioning for potential favorable clinical outcomes.
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