ArticleFrontiers in aging neuroscience2020
Age-Related Changes in Pain Perception Are Associated With Altered Functional Connectivity During Resting State.
Article in Frontiers in aging neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 2 of them syntheses that pooled it.
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Who cites it
47 citing papers in PubMed, 2 syntheses or guidelines pooled it, 87 citations in OpenAlex.
- Neural correlates of harm avoidance: a multimodal meta-analysis of brain structural and resting-state functional neuroimaging studies.Translational psychiatry · 2024Pooled it
- Pooled it
- Safety and efficacy of various topical anesthesia for intravitreal injection: a randomized controlled trial.International ophthalmology · 2026Trial
- Chronic Pain in Older Adults: Risk Factors and Prevention.Life (Basel, Switzerland) · 2026Review
- Exploring Pain Researcher and Clinician Perceptions of Complementary, Alternative, and Integrative Medicine: A Large-Scale, International Cross-Sectional Survey.Pain practice : the official journal of World Institute of Pain · 2026Article
- Assessing the impact of manual therapy in the management of nonspecific low back pain: a scoping review of the outcomes used in clinical trials.BMC complementary medicine and therapies · 2026Article
- A randomised, double-blind, sham-controlled, 2×2 factorial trial of aerobic vs. non-aerobic exercise and motor cortex transcranial direct current stimulation in fibromyalgia: effects on clinical outcomes and descending pain modulation.Lancet regional health. Americas · 2026Article
- Clinical features and subgroup patterns in elderly and super-elderly TMD patients.Scientific reports · 2025Article
- An Improved Deep Semi-supervised JNMF Method for Biomarker Extraction of Alzheimer's Disease.Journal of molecular neuroscience : MN · 2025Article
- The relationship between muscle mass and low back pain: a cross-sectional study.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2025Article
- Reference Values of Joint-Specific Pressure Pain Thresholds in Healthy Male Individuals: A Retrospective Study.European journal of pain (London, England) · 2025Article
- Aging is a Risk Factor for Rheumatoid Arthritis in Rats: Therapeutic Potential of 4‑(Phenylselanyl)-2H-chromen-2-one.ACS omega · 2025Article
- Exploring the Spectrum of Temporal Summation and Conditioned Pain Modulation Responses in Pain-Free Individuals Using a Tonic Heat Pain and Cold Pressor Test Paradigms.European journal of pain (London, England) · 2025Observational
- Revision Surgery Is the Most Common Definition of Failure in Studies Evaluating Knee Cartilage Restoration Outcomes: A Systematic Review.Arthroscopy, sports medicine, and rehabilitation · 2025Review
- Effects of aging on experimentally induced pain perception during a distraction task.Scientific reports · 2025Article
- Pain and the Brain: A Systematic Review of Methods, EEG Biomarkers, Limitations, and Future Directions.Neurology international · 2025Review
- Analgesic effect of simultaneously targeting multiple pain processing brain circuits in an aged humanized mouse model of chronic pain by transcranial focused ultrasound.APL bioengineering · 2025Article
- Cognitive profile in burning mouth syndrome versus mild cognitive impairment: A comparative study.Oral diseases · 2025Article
- The Role of Maladaptive Plasticity in Modulating Pain Pressure Threshold Post-Spinal Cord Injury.Healthcare (Basel, Switzerland) · 2025Article
- Review
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aging affects pain experience and brain functioning. However, how aging leads to changes in pain perception and brain functional connectivity has not yet been completely understood. To investigate resting-state and pain perception changes in old and young participants, this study employed region of interest (ROI) to ROI resting-state functional connectivity (rsFC) analysis of imaging data by using regions implicated in sensory and affective dimensions of pain, descending pain modulation, and the default-mode networks (DMNs). Thirty-seven older (66.86 ± 4.04 years; 16 males) and 38 younger healthy participants (20.74 ± 4.15 years; 19 males) underwent 10 min' eyes-closed resting-state scanning. We examined the relationship between rsFC parameters with pressure pain thresholds. Older participants showed higher pain thresholds than younger. Regarding rsFC, older adults displayed increased connectivity of pain-related sensory brain regions in comparison to younger participants: increased rsFC between bilateral primary somatosensory area (SI) and anterior cingulate cortex (ACC), and between SI(L) and secondary somatosensory area (SII)-(R) and dorsolateral prefrontal cortex (PFC). Moreover, decreased connectivity in the older compared to the younger group was found among descending pain modulatory regions: between the amygdala(R) and bilateral insula(R), thalamus(R), ACC, and amygdala(L); between the amygdala(L) and insula(R) and bilateral thalamus; between ACC and bilateral insula, and between periaqueductal gray (PAG) and bilateral thalamus. Regarding the DMN, the posterior parietal cortex and lateral parietal (LP; R) were more strongly connected in the older group than in the younger group. Correlational analyses also showed that SI(L)-SII(R) rsFC was positively associated with pressure pain thresholds in older participants. In conclusion, these findings suggest a compensatory mechanism for the sensory changes that typically accompanies aging. Furthermore, older participants showed reduced functional connectivity between key nodes of the descending pain inhibitory pathway.
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