ArticleFrontiers in integrative neuroscience2020
Progesterone and Allopregnanolone Rapidly Attenuate Estrogen-Associated Mechanical Allodynia in Rats with Persistent Temporomandibular Joint Inflammation.
Article in Frontiers in integrative neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Association between Estrogen Levels and Temporomandibular Disorders: An Updated Systematic Review.International journal of molecular sciences · 2024Pooled it
- Correlating estrogen replacement therapy and temporomandibular disorders: a comprehensive review following PRISMA principles and cochrane handbook for systematic reviews of interventions.BMC oral health · 2024Pooled it
- Bidirectional causality between female reproductive traits and temporomandibular disorders.Journal of oral & facial pain and headache · 2025Article
- RAMP1-dependent hormonal regulation of CGRP and its receptor in the trigeminal ganglion.The journal of headache and pain · 2025Article
- Allopregnanolone relieves paclitaxel induced mechanical hypersensitivity via inhibiting spinal cord PGEIBRO neuroscience reports · 2025Article
- Clinical, psychological, and hematological factors predicting sleep bruxism in patients with temporomandibular disorders.Scientific reports · 2025Observational
- Pain in polycystic ovary syndrome: a comprehensive bedside to bench perspective on an underrecognized symptom.Frontiers in pharmacology · 2025Review
- Causal relationships between immunophenotypes, plasma metabolites, and temporomandibular disorders based on Mendelian randomization.Scientific reports · 2024Article
- Does hormone replacement therapy impact implant osseointegration in females- A systematic review and meta-analysis.The Saudi dental journal · 2024Review
- Progesterone Receptor Activation Regulates Sensory Sensitivity and Migraine Susceptibility.The journal of pain · 2024Article
- Metabolic profiling of synovial fluid in human temporomandibular joint osteoarthritis.Frontiers in immunology · 2024Article
- Considerations for hormonal therapy in migraine patients: a critical review of current practice.Expert review of neurotherapeutics · 2023Review
- Being friendly: paced mating for the study of physiological, behavioral, and neuroplastic changes induced by sexual behavior in females.Frontiers in behavioral neuroscience · 2023Review
- Influence of TRPV1 on Thermal Nociception in Rats with Temporomandibular Joint Persistent Inflammation Evaluated by the Operant Orofacial Pain Assessment Device (OPAD).Journal of pain research · 2023Article
- Molecular mechanisms of hormones implicated in migraine and the translational implication for transgender patients.Frontiers in pain research (Lausanne, Switzerland) · 2023Review
- Progesterone as an Anti-Inflammatory Drug and Immunomodulator: New Aspects in Hormonal Regulation of the Inflammation.Biomolecules · 2022Review
- Article
- Sexual dimorphism in a neuronal mechanism of spinal hyperexcitability across rodent and human models of pathological pain.Brain : a journal of neurology · 2022Article
- Preclinical models of deep craniofacial nociception and temporomandibular disorder pain.The Japanese dental science review · 2021Review
- Hormonal influences in migraine - interactions of oestrogen, oxytocin and CGRP.Nature reviews. Neurology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Temporomandibular joint disorder (TMD) is associated with pain in the joint (temporomandibular joint, TMJ) and muscles involved in mastication. TMD pain dissipates following menopause but returns in some women undergoing estrogen replacement therapy. Progesterone has both anti-inflammatory and antinociceptive properties, while estrogen's effects on nociception are variable and highly dependent on both natural hormone fluctuations and estrogen dosage during pharmacological treatments, with high doses increasing pain. Allopregnanolone, a progesterone metabolite and positive allosteric modulator of the GABA
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.