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ArticleHypertension research : official journal of the Japanese Society of Hypertension2020

Usefulness of the SAGE score to predict elevated values of brachial-ankle pulse wave velocity in Japanese subjects with hypertension.

Hirofumi Tomiyama, Charalambos Vlachopoulos, Panagiotis Xaplanteris, Hiroki Nakano, Kazuki Shiina, Tomoko Ishizu, Takahide Kohro, Yukihito Higashi, Bonpei Takase, Toru Suzuki and 20 more

Abstract read
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In one paragraph

Article in Hypertension research : official journal of the Japanese Society of Hypertension, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Does elevated pulse wave velocity improve risk prediction in low-risk populations?Hypertension research : official journal of the Japanese Society of Hypertension · 2025
    Article
  2. Article
  3. Article
  4. Markers of Vascular Dysfunction in Hypertension.Current medicinal chemistry · 2025
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Vascular Aging and Arterial Stiffness.Arquivos brasileiros de cardiologia · 2022
    Article
  10. A SAGE score cutoff that predicts high-pulse wave velocity as measured by oscillometric devices in Brazilian hypertensive patients.Hypertension research : official journal of the Japanese Society of Hypertension · 2022
    Article
  11. Association of Nondiabetic Glucometabolic Status and Aortic Stiffness in Community Hypertension Patients.Diabetes, metabolic syndrome and obesity : targets and therapy · 2022
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

Hirofumi TomiyamaDepartment of Cardiology, Tokyo Medical University, Tokyo, Japan. tomiyama@tokyo-med.ac.jp.
Charalambos VlachopoulosHypertension and Cardiometabolic Unit, (1st) Department of Cardiology, National and Kapodistrian University of Athens, Hippokration Hospital, Athens, Cyprus.
Panagiotis XaplanterisHypertension and Cardiometabolic Unit, (1st) Department of Cardiology, National and Kapodistrian University of Athens, Hippokration Hospital, Athens, Cyprus.
Hiroki NakanoDepartment of Cardiology, Tokyo Medical University, Tokyo, Japan.
Kazuki ShiinaDepartment of Cardiology, Tokyo Medical University, Tokyo, Japan.
Tomoko IshizuCardiovascular Division, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan.
Takahide KohroDepartment of Clinical Informatics, Jichi Medical University School of Medicine, Tochigi, Japan.
Yukihito HigashiDepartment of Cardiovascular Physiology and Medicine, Hiroshima University Graduate School of Biomedical Science, Hiroshima, Japan.
Bonpei TakaseDivision of Biomedical Engineering, National Defense Medical College Research Institute, Saitama, Japan.
Toru SuzukiCardiovascular Medicine, University of Leicester, Leicester, UK.
Tsutomu YamazakiDepartment of Clinical Epidemiology and Systems, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
Tomoo FurumotoDepartment of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Hokkaido, Japan.
Kazuomi KarioDivision of Cardiovascular Medicine, Jichi Medical University School of Medicine, Tochigi, Japan.
Teruo InoueDepartment of Cardiovascular Medicine, Dokkyo Medical University, Mibu, Tochigi, Japan.
Shinji KobaDepartment of Medicine, Division of Cardiology, Showa University School of Medicine, Tokyo, Japan.
Yasuhiko TakemotoDepartment of Internal Medicine and Cardiology, Osaka City University Graduate School of Medicine, Osaka, Japan.
Takuzo HanoDepartment of Medical Education and Population-based Medicine, Postgraduate School of Medicine, Wakayama Medical University, Wakayama, Japan.
Masataka SataDepartment of Cardiovascular Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan.
Yutaka IshibashiDepartment of General Medicine, Shimane University Faculty of Medicine, Izumo, Japan.
Koichi NodeDepartment of Cardiovascular and Renal Medicine, Saga University, Saga, Japan.
Atsushi TanakaDepartment of Cardiovascular and Renal Medicine, Saga University, Saga, Japan.
Koji MaemuraDepartment of Cardiovascular Medicine, Course of Medical and Dental Sciences, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
Yusuke OhyaThe Third Department of Internal Medicine, University of the Ryukyus, Okinawa, Japan.
Taiji FurukawaDepartment of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan.
Hiroshi ItoDepartment of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okinawa, Japan.
Toshiaki OhkumaDepartment of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Toshiharu NinomiyaDepartment of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Taishiro ChikamoriDepartment of Cardiology, Tokyo Medical University, Tokyo, Japan.
Akira YamashinaDepartment of Cardiology, Tokyo Medical University, Tokyo, Japan.
Shin-Ichiro UedaDepartment of Clinical Pharmacology and Therapeutics, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan. blessyou@med.u-ryukyu.ac.jp.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The score based on the office systolic blood pressure, age, fasting blood glucose level, and estimated glomerular filtration rate (SAGE score) has been proposed as a useful marker to identify elevated values of carotid-femoral pulse wave velocity (PWV). The present cross-sectional study was conducted to examine whether the SAGE score is also a useful marker to identify subjects with elevated brachial-ankle PWV values in Japanese subjects with hypertension. We measured the brachial-ankle PWV and calculated the SAGE score in a total of 1019 employees of a Japanese company with hypertension and 817 subjects with hypertension derived from a multicenter study cohort. The analyses in this study were based on data from these two study groups as well as on a composite population of the two (n = 1836). The receiver operating characteristic curve analysis showed that the area under the curve to identify subjects with brachial-ankle PWV values of ≥1800 cm/s was over 0.70 in each of the three study groups. Even after adjustments, a SAGE score ≥7 had a significant odds ratio for identifying subjects with brachial-ankle PWV values ≥1800 cm/s in the 1836 study subjects from the composite occupational and multicenter study cohort (odds ratio = 2.1, 95% confidence interval = 1.4-3.0, P < 0.01). Thus, in Japanese subjects with hypertension, the SAGE score may be a useful marker for identifying subjects with elevated brachial-ankle PWV values.

Indexed as

Health Status IndicatorsPulse Wave AnalysisAdultAgedCross-Sectional StudiesFemaleHumansHypertensionJapanMaleMiddle AgedArterial stiffnessPulse wave velocityRisk factors

Identifiers

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.