ArticleScientific reports2020
Association between serum copper levels and prevalence of hyperuricemia: a cross-sectional study.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- A systematic review and meta-analysis of the hyperuricemia risk from certain metals.Clinical rheumatology · 2022Pooled it
- Associations between multiple essential trace metal concentrations and risk of hyperuricemia: insights from a central Chinese population.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026Article
- The Association of Mixed Mineral Intake Exposure With Gout: A National Cross-Sectional National Health and Nutrition Examination Survey (NHANES) Study.Food science & nutrition · 2025Article
- Article
- A cross-sectional study of the association between blood metal mixtures exposure and hyperuricemia.Clinical rheumatology · 2024Article
- Association between serum copper and blood glucose: a mediation analysis of inflammation indicators in the NHANES (2011-2016).Frontiers in public health · 2024Article
- Hyperuricemia research progress in model construction and traditional Chinese medicine interventions.Frontiers in pharmacology · 2024Review
- Associations between blood essential metal mixture and serum uric acid: a cross-sectional study.Frontiers in public health · 2023Article
- The relative and interactive effects of urinary multiple metals exposure on hyperuricemia among urban elderly in China.Frontiers in public health · 2023Article
- Recent advances in the application of ionomics in metabolic diseases.Frontiers in nutrition · 2022Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hyperuricemia has been recognized as a worldwide public health concern. This study was conducted to examine the association between serum copper (Cu) concentration and the prevalence of hyperuricemia in a middle-aged and elderly population. Serum Cu concentration was measured by Roche modular P800 using the PAESA method. Serum uric acid (UA) concentration was detected by a Beckman Coulter AU 5800. Presence of hyperuricemia was defined as serum UA ≥ 416 μmol/L for men and ≥360 μmol/L for women. The association between serum Cu concentration and the prevalence of hyperuricemia was evaluated by logistic regression. The prevalence of hyperuricemia was 17.6% (n = 6,212) in the present study. Relative to the lowest quintile, the age- and sex-adjusted odds ratios for hyperuricemia were 1.38 (95% CI: 1.12 to 1.70), 1.34 (95% CI: 1.07 to 1.66), and 1.53 (95% CI: 1.23 to 1.91) in the third, fourth, and fifth serum Cu concentration quintiles (P for trend < 0.001). Similar results were found both in men and women subgroups. None of the findings were materially altered after adjustment for additional potential confounders. In conclusion, in this population-based cross-sectional study, serum Cu concentration was positively associated with the prevalence of hyperuricemia.
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