Evidence map›Paper›PMID 32457287›Full record

ReviewNature communications2020

The UK Biobank imaging enhancement of 100,000 participants: rationale, data collection, management and future directions.

Thomas J Littlejohns, Jo Holliday, Lorna M Gibson, Steve Garratt, Niels Oesingmann, Fidel Alfaro-Almagro, Jimmy D Bell, Chris Boultwood, Rory Collins, Megan C Conroy and 14 more

Abstract readReview
In one paragraph

Review in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 487 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
487citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

487 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. Observational
  7. Review
  8. Article
  9. Article
  10. Article
  11. Classification of Alcohol Use Disorder With Explainable AI.Alcohol, clinical & experimental research · 2026
    Article
  12. Article
  13. Review
  14. Review
  15. Detecting scoliosis at scale using automated Cobb angle analysis in the UK Biobank.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026
    Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article

427 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Thomas J LittlejohnsNuffield Department of Population Health, University of Oxford, Oxford, UK. thomas.littlejohns@ndph.ox.ac.uk.ORCID http://orcid.org/0000-0003-1177-6923
Jo HollidayNuffield Department of Population Health, University of Oxford, Oxford, UK.
Lorna M GibsonUsher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
Steve GarrattUK Biobank Coordinating Centre, Stockport, UK.ORCID http://orcid.org/0000-0001-9638-4173
Niels OesingmannUK Biobank Coordinating Centre, Stockport, UK.
Fidel Alfaro-AlmagroCentre for Functional MRI of the Brain, Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, UK.
Jimmy D BellResearch Centre for Optimal Health, University of Westminster, London, UK.ORCID http://orcid.org/0000-0003-3804-1281
Chris BoultwoodUK Biobank Coordinating Centre, Stockport, UK.
Rory CollinsNuffield Department of Population Health, University of Oxford, Oxford, UK.
Megan C ConroyNuffield Department of Population Health, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-3847-6202
Nicola CrabtreeBirmingham Women's and Children's NHS Foundation Trust, Birmingham, UK.ORCID http://orcid.org/0000-0001-6729-5841
Nicola DohertyUK Biobank Coordinating Centre, Stockport, UK.
Alejandro F FrangiDepartment of Cardiovascular Sciences and Electrical Engineering, KU Leuven, Leuven, Belgium.ORCID http://orcid.org/0000-0002-2675-528X
Nicholas C HarveyMRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.
Paul LeesonRadcliffe Department of Medicine, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0001-9181-9297
Karla L MillerCentre for Functional MRI of the Brain, Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, UK.
Stefan NeubauerRadcliffe Department of Medicine, University of Oxford, Oxford, UK.
Steffen E PetersenWilliam Harvey Research Institute, Queen Mary University of Medicine, London, UK.ORCID http://orcid.org/0000-0003-4622-5160
Jonathan SellorsNuffield Department of Population Health, University of Oxford, Oxford, UK.
Simon SheardUK Biobank Coordinating Centre, Stockport, UK.ORCID http://orcid.org/0000-0002-8925-8280
Stephen M SmithCentre for Functional MRI of the Brain, Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0001-8166-069X
Cathie L M SudlowUsher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
Paul M Matthews *Department of Brain Sciences, Imperial College London and UK Dementia Research Institute, London, UK.ORCID http://orcid.org/0000-0002-1619-8328
Naomi E Allen *Nuffield Department of Population Health, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0003-1938-5038

Funding

British Heart Foundation FS/11/65/28865British Heart Foundation PG/17/13/32860Department of HealthMedical Research Council G0900897Medical Research Council G9409531Medical Research Council G9409634Medical Research Council G9901399Medical Research Council MC_PC_15067Medical Research Council MC_PC_17114Medical Research Council MC_PC_17228Medical Research Council MR/K501013/1Medical Research Council MR/N026934/1Wellcome Trust 107190/Z/15/ZWellcome Trust 202788/Z/16/Z
6 · The paper itself

Abstract

UK Biobank is a population-based cohort of half a million participants aged 40-69 years recruited between 2006 and 2010. In 2014, UK Biobank started the world's largest multi-modal imaging study, with the aim of re-inviting 100,000 participants to undergo brain, cardiac and abdominal magnetic resonance imaging, dual-energy X-ray absorptiometry and carotid ultrasound. The combination of large-scale multi-modal imaging with extensive phenotypic and genetic data offers an unprecedented resource for scientists to conduct health-related research. This article provides an in-depth overview of the imaging enhancement, including the data collected, how it is managed and processed, and future directions.

Indexed as

Biological Specimen BanksImage EnhancementInformation ManagementAdultAgedFemaleHumansIncidental FindingsMaleMiddle AgedMultimodal ImagingUnited Kingdom

Identifiers

PMID32457287
PMCPMC7250878

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.