Evidence map›Paper›PMID 32457254›Full record

ArticleAging2020

Attenuation of doxorubicin-induced cardiotoxicity by

Le Li, Bin Wu, Qiangqiang Zhao, Jian Li, Yunfeng Han, Xiaohang Fan, Junli Dong, Pengcheng Li

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.6field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 15 citations in OpenAlex.

  1. Cryptotanshinone Attenuated Pathological Cardiac RemodelingOxidative medicine and cellular longevity · 2023
    Article
  2. Review
  3. Potential chemoprotective effects of active ingredients inFrontiers in cardiovascular medicine · 2023
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Le LiDepartment of Cardiology, The Third Xiangya Hospital, Central South University, Changsha, China.
Bin WuLaboratory of Platelet and Endothelium Biology, Department of Transfusion Medicine, Wuhan Hospital of Traditional Chinese and Western Medicine (Wuhan No.1 Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Qiangqiang ZhaoDepartment of Blood Transfusion, The Third Xiangya Hospital, Central South University, Changsha, China.
Jian LiDepartment of Blood Transfusion, The Third Xiangya Hospital, Central South University, Changsha, China.
Yunfeng HanDepartment of Nuclear Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Xiaohang FanDepartment of Pathophysiology, Scholl of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Junli DongLaboratory of Clinical Pharmacogenetics, Department of Pharmacy, Wuhan Hospital of Traditional Chinese and Western Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Pengcheng LiLaboratory of Platelet and Endothelium Biology, Department of Transfusion Medicine, Wuhan Hospital of Traditional Chinese and Western Medicine (Wuhan No.1 Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Huazhong University of Science and Technology · CNThird Xiangya Hospital · CNWuhan No.1 Hospital · CNCentral South University · CNTongji Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe cardiotoxicity of doxorubicin (DOX) reduces the quality of life and prognosis of cancer patients, and therefore its clinical application has been largely restricted. This study aimed to assess the effects of cryptotanshione (CPT) on DOX-induced rat cardiac insufficiency.

resultsCPT treatment significantly suppressed apoptosis

conclusionTranscriptomic profiling and bioinformatics analysis can be used to evaluate the cardio-protective effect of CPT through inactivating p53 signaling pathway in the doxorubicin-mediated myocardial damage model.

methodsF-actin staining and flow cytometry were used to assess the effects of CPT on cardiomyocytes.

Indexed as

AnimalsApoptosisCardiotonic AgentsCardiotoxicityComputational BiologyDatabases, GeneticDisease Models, AnimalDoxorubicinGene Expression ProfilingHeartHeart DiseasesMetabolic Networks and PathwaysMyocytes, CardiacPhenanthrenesRatsReactive Oxygen SpeciesCardiotonic AgentscryptotanshinoneDoxorubicinPhenanthrenesReactive Oxygen Speciescardiotoxicitycryptotanshinonedoxorubicinreactive oxygen speciestranscriptomic profiling

Identifiers

PMID32457254
PMCPMC7288906
OpenAlexW3032242107

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.