ArticlemBio2020
Cryo-EM Structures of a Gonococcal Multidrug Efflux Pump Illuminate a Mechanism of Drug Recognition and Resistance.
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Article in mBio, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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52citing papers in PubMed
10.4field-weighted citation impact, top 1% of its field
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Who cites it
52 citing papers in PubMed, 68 citations in OpenAlex.
- Efflux modulation as an antimicrobial strategy: mechanisms and translational perspectives.npj drug discovery · 2026Review
- Structural insights into a substrate translocation pathway revealed by the RND efflux pump complex MexJK fromScience advances · 2026Article
- How resistance-nodulation-division (RND) efflux pumps contribute to virulence.PLoS pathogens · 2026Review
- Cryo-EM structures of a MexB-MexY chimeric efflux pump reveal that large open clefts are intrinsic to the MexY porter domain.Acta crystallographica. Section F, Structural biology communications · 2026Article
- Whole-genome characterization of seven multidrug-resistantFrontiers in microbiology · 2026Article
- Global genomic and antimicrobial resistance profiling of Neisseria gonorrhoeae: Insights from whole genome sequencing and minimum inhibitory concentration analysis.PLoS neglected tropical diseases · 2025Article
- Cryo-EM structure of themBio · 2025Article
- Article
- Antibiotic resistance mediated by gene amplifications.npj antimicrobials and resistance · 2024Review
- Common Patterns and Unique Threats in Antimicrobial Resistance as Demonstrated by Global Gonococcal Surveillance.Emerging infectious diseases · 2024Article
- Structural and functional diversity of Resistance-Nodulation-Division (RND) efflux pump transporters with implications for antimicrobial resistance.Microbiology and molecular biology reviews : MMBR · 2024Review
- The novel 2024 WHO Neisseria gonorrhoeae reference strains for global quality assurance of laboratory investigations and superseded WHO N. gonorrhoeae reference strains-phenotypic, genetic and reference genome characterization.The Journal of antimicrobial chemotherapy · 2024Article
- Structural analysis of resistance-nodulation cell division transporters.Microbiology and molecular biology reviews : MMBR · 2024Review
- Molecular Mechanisms of Bacterial Resistance to Antimicrobial Peptides in the Modern Era: An Updated Review.Microorganisms · 2024Review
- Low Oxygen Concentration ReducesAntibiotics (Basel, Switzerland) · 2024Article
- Molecular insights into the determinants of substrate specificity and efflux inhibition of the RND efflux pumps AcrB and AdeB.Microbiology (Reading, England) · 2024Review
- Cryo-Electron Microscopy Structures of a Campylobacter Multidrug Efflux Pump Reveal a Novel Mechanism of Drug Recognition and Resistance.Microbiology spectrum · 2023Article
- Crystal structures of multidrug efflux transporters fromProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Article
- Efflux pump gene amplifications bypass necessity of multiple target mutations for resistance against dual-targeting antibiotic.Nature communications · 2023Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Meinan Lyu *Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
Mitchell A Moseng *Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
Jennifer L ReimcheDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, USA.
Concerta L HolleyDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, USA.
Vijaya DhulipalaDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, USA.
Chih-Chia SuDepartment of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
William M ShaferDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, USA.
Edward W YuDepartment of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA edward.w.yu@case.edu.ORCID 0000-0001-5912-1227
Emory University · USUniversity School · US
Funding
GONOCOCCI: GENETICS OF RESISTANCE TO PMN PROTEINSR01AI021150 · NIAID · EMORY UNIVERSITY · PI SHAFER, WILLIAM MAURICE · 1985 to 2025
$5.5MGonococci: Genetics of Resistance to PMN ProteinsR37AI021150 · NIAID · EMORY UNIVERSITY · PI SHAFER, WILLIAM MAURICE · 2010 to 2019
$3.9MEmerging antibiotic resistance in Gram-negative pathogensR01AI145069 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI YU, EDWARD W · 2019 to 2023
$3.3MBLRD VA IK6 BX005390NIAID NIH HHS R01 AI145069NIAID NIH HHS R37 AI021150
Abstract
PubMed holds no abstract for this paper.
Indexed as
Drug Resistance, Multiple, BacterialAnti-Bacterial AgentsBacterial ProteinsCryoelectron MicroscopyGene Expression Regulation, BacterialMembrane Transport ProteinsNeisseria gonorrhoeaeAnti-Bacterial AgentsBacterial ProteinsMembrane Transport Proteinscryo-EMefflux pumpsmultidrug resistanceNeisseria gonorrhoeaestructural biology
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.