Evidence map›Paper›PMID 32457162›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Putative regulators for the continuum of erythroid differentiation revealed by single-cell transcriptome of human BM and UCB cells.

Peng Huang, Yongzhong Zhao, Jianmei Zhong, Xinhua Zhang, Qifa Liu, Xiaoxia Qiu, Shaoke Chen, Hongxia Yan, Christopher Hillyer, Narla Mohandas and 2 more

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
6.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 74 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Development and IND-enabling studies of a novel Cas9 genome-edited autologous CD34Molecular therapy : the journal of the American Society of Gene Therapy · 2024
    Article
  7. Erythroblast enucleation at a glance.Journal of cell science · 2024
    Review
  8. Article
  9. Review
  10. [Progress in multiomics research on high altitude polycythemia].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2024
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 2 countries.

Peng HuangDepartment of Medical Genetics, School of Basic Medical Sciences, Southern Medical University, 510515 Guangzhou, China.ORCID 0000-0001-6932-6701
Yongzhong ZhaoDepartment of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195.
Jianmei ZhongDepartment of Medical Genetics, School of Basic Medical Sciences, Southern Medical University, 510515 Guangzhou, China.
Xinhua ZhangDepartment of Hematology, 303rd Hospital of the People's Liberation Army, 530021 Nanning, China.
Qifa LiuDepartment of Hematology, Nanfang Hospital, Southern Medical University, 510515 Guangzhou, China.
Xiaoxia QiuPrenatal Diagnostic Center, Institute of Birth Defect Prevention and Control, Guangxi Zhuang Autonomous Region Women and Children Health Care Hospital, 530000 Nanning, China.
Shaoke ChenPrenatal Diagnostic Center, Institute of Birth Defect Prevention and Control, Guangxi Zhuang Autonomous Region Women and Children Health Care Hospital, 530000 Nanning, China.
Hongxia YanRed Cell Physiology Laboratory, New York Blood Center, New York, NY 10065.
Christopher HillyerRed Cell Physiology Laboratory, New York Blood Center, New York, NY 10065.
Narla MohandasRed Cell Physiology Laboratory, New York Blood Center, New York, NY 10065.ORCID 0000-0003-2271-5296
Xinghua PanGuangdong Provincial Key Laboratory of Single Cell Technology and Application, 510515 Guangzhou, China; panvictor@qq.com xixm@smu.edu.cn.ORCID 0000-0002-7421-8155
Xiangmin XuDepartment of Medical Genetics, School of Basic Medical Sciences, Southern Medical University, 510515 Guangzhou, China; panvictor@qq.com xixm@smu.edu.cn.
Key Laboratory of Guangdong Province · CNNew York Blood Center · USGuangxi Maternal and Child Health Hospital · CN303 Hospital of People's Liberation Army · CNCell Technology (China) · CNCleveland Clinic Lerner College of Medicine · USNanfang Hospital · CN

Funding

YEAST MEMBRANE CYTOSKELETONP01DK032094 · NIDDK · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI NARLA, MOHANDAS · 1987 to 2021
$26.7M
NIDDK NIH HHS P01 DK032094
6 · The paper itself

Abstract

Fine-resolution differentiation trajectories of adult human hematopoietic stem cells (HSCs) involved in the generation of red cells is critical for understanding dynamic developmental changes that accompany human erythropoiesis. Using single-cell RNA sequencing (scRNA-seq) of primary human terminal erythroid cells (CD34

Indexed as

AdultApoptosisCarrier ProteinsCell DifferentiationDNA-Binding ProteinsErythroblastsErythropoiesisFetal BloodGene Knockdown TechniquesGene Regulatory NetworksHumansInfant, NewbornIntracellular Signaling Peptides and ProteinsMaleMultigene FamilyNuclear ProteinsAKAP8L protein, humanCarrier ProteinsDNA-Binding ProteinsIntracellular Signaling Peptides and ProteinsNuclear ProteinsRNF10 protein, humanShelterin ComplexTelomere-Binding ProteinsTERF2IP protein, humancell clustersregulatorscRNA-seqterminal erythroid differentiation

Identifiers

PMID32457162
PMCPMC7293633
OpenAlexW3030848665

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.