ArticleProceedings of the National Academy of Sciences of the United States of America2020
Tuning environmental timescales to evolve and maintain generalists.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Competition constrains parasite adaptation to thermal heterogeneity.Evolution letters · 2026Article
- Population dynamics of generalist and specialist strategies under feast-famine cycles.PLoS computational biology · 2026Article
- The influence of changing fire regimes on specialized plant-animal interactions.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Review
- Evolution takes multiple paths to evolvability when facing environmental change.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- The MetaInvert soil invertebrate genome resource provides insights into below-ground biodiversity and evolution.Communications biology · 2023Article
- Steering and controlling evolution - from bioengineering to fighting pathogens.Nature reviews. Genetics · 2023Review
- Learning to learn by using nonequilibrium training protocols for adaptable materials.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Mechanisms that promote the evolution of cross-reactive antibodies upon vaccination with designed influenza immunogens.Cell reports · 2023Article
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- Design of immunogens for eliciting antibody responses that may protect against SARS-CoV-2 variants.PLoS computational biology · 2022Article
- Model architecture can transform catastrophic forgetting into positive transfer.Scientific reports · 2022Article
- Affinity maturation for an optimal balance between long-term immune coverage and short-term resource constraints.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Moving the needle: Employing deep reinforcement learning to push the boundaries of coarse-grained vaccine models.Frontiers in immunology · 2022Article
- Binding affinity landscapes constrain the evolution of broadly neutralizing anti-influenza antibodies.eLife · 2021Article
- Coevolutionary transitions emerging from flexible molecular recognition and eco-evolutionary feedback.iScience · 2021Article
- Overcoming the growth-infectivity trade-off in a bacteriophage slows bacterial resistance evolution.Evolutionary applications · 2021Article
- Predicting in vivo escape dynamics of HIV-1 from a broadly neutralizing antibody.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Roadmap on biology in time varying environments.Physical biology · 2021Review
- Mechanisms underlying vaccination protocols that may optimally elicit broadly neutralizing antibodies against highly mutable pathogens.Physical review. E · 2021Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Natural environments can present diverse challenges, but some genotypes remain fit across many environments. Such "generalists" can be hard to evolve, outcompeted by specialists fitter in any particular environment. Here, inspired by the search for broadly neutralizing antibodies during B cell affinity maturation, we demonstrate that environmental changes on an intermediate timescale can reliably evolve generalists, even when faster or slower environmental changes are unable to do so. We find that changing environments on timescales comparable with evolutionary transients in a population enhance the rate of evolving generalists from specialists, without enhancing the reverse process. The yield of generalists is further increased in more complex dynamic environments, such as a "chirp" of increasing frequency. Our work offers design principles for how nonequilibrium fitness "seascapes" can dynamically funnel populations to genotypes unobtainable in static environments.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.