ArticleProceedings of the National Academy of Sciences of the United States of America2020
Forward genetic analysis using OCT screening identifies
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
What it found
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Who cites it
17 citing papers in PubMed, 17 citations in OpenAlex.
- Photoreceptor Vulnerability to Ferroptosis: Membrane Phospholipid Peroxidation, Mitochondrial Homeostasis, and RPE-Photoreceptor Coupling.Current issues in molecular biology · 2026Review
- The Transcription Factor 12 of Basic Helix-Loop-Helix Plays an Essential Role in Retinal Health.Investigative ophthalmology & visual science · 2026Article
- Preclinical in vivo dosimetry of healthy tissues in radiopharmaceutical therapy: implementation of a physiologically realistic mouse eye model in GATE.EJNMMI research · 2026Article
- A mutation inMolecular vision · 2026Article
- Identifying genetic determinants of outer retinal function in mice using a large-scale gene-targeted screen.PLoS genetics · 2025Article
- Advancements in CRISPR/Cas systems for disease treatment.Acta pharmaceutica Sinica. B · 2025Review
- In Vivo Imaging of Rodent Retina in Retinal Disease.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Nonredundant Role of Leishmanolysin-Like (Lmln) Zinc-Metallopeptidase in Retinal Homeostasis.American journal of ophthalmology · 2025Article
- E3 ubiquitin ligase Herc3 deficiency leads to accumulation of subretinal microglia and retinal neurodegeneration.Scientific reports · 2024Article
- Single Cell RNA Sequencing Analysis of Mouse Retina Identifies a Subpopulation of Muller Glia Involved in Retinal Recovery From Injury in the FCD-LIRD Model.Investigative ophthalmology & visual science · 2023Article
- Forward genetic screening using fundus spot scale identifies an essential role for Lipe in murine retinal homeostasis.Communications biology · 2023Article
- Prospective role and immunotherapeutic targets of sideroflexin protein family in lung adenocarcinoma: evidence from bioinformatics validation.Functional & integrative genomics · 2022Article
- Construction of a competing endogenous RNA network in head and neck squamous cell carcinoma by pan-cancer analysis.Translational cancer research · 2022Article
- A High-Throughput Search for SFXN1 Physical Partners Led to the Identification of ATAD3, HSD10 and TIM50.Biology · 2022Article
- The mitochondrial protein Sideroflexin 3 (SFXN3) influences neurodegeneration pathways in vivo.The FEBS journal · 2022Article
- Insights into the Roles of the Sideroflexins/SLC56 Family in Iron Homeostasis and Iron-Sulfur Biogenesis.Biomedicines · 2021Review
- Metabolic Features of Mouse and Human Retinas: Rods versus Cones, Macula versus Periphery, Retina versus RPE.iScience · 2020Article
Corrections and comments
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Authors and funding
18 authors at 2 institutions in 1 country.
Bo ChenDepartment of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX 75390.ORCID 0000-0002-1931-3002
Bogale AredoDepartment of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Yi DingDepartment of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Xin ZhongDepartment of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Yuanfei ZhuDepartment of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX 75390.ORCID 0000-0002-6815-5784
Cynthia X ZhaoDepartment of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Ashwani KumarMcDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Chao XingMcDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX 75390.ORCID 0000-0002-1838-0502
Laurent GautronCenter for Hypothalamic Research and Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390.ORCID 0000-0003-3609-7441
Stephen LyonCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Jamie RussellCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Xiaohong LiCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Miao TangCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Priscilla AndertonCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Sara LudwigCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Eva Marie Y MorescoCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390.ORCID 0000-0002-2049-7291
Bruce BeutlerCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390 Bruce.Beutler@UTSouthwestern.edu Rafael.Ufret-Vincenty@UTSouthwestern.edu.ORCID 0000-0002-3639-246X
Rafael L Ufret-VincentyDepartment of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX 75390; Bruce.Beutler@UTSouthwestern.edu Rafael.Ufret-Vincenty@UTSouthwestern.edu.ORCID 0000-0001-8022-5119
The University of Texas Southwestern Medical Center · USSouthwestern Medical Center · US
Funding
Systems Biology CoreU19AI100627 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI ULEVITCH, RICHARD J · 2012 to 2021
$49.1MAutomated Forward Genetic Analysis of Adaptive ImmunityR01AI125581 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI BRUCE A BEUTLER · 2016 to 2026
$19.5MStem Cell, Organoid and Cell Phenotyping ModuleP30EY030413 · NEI · UT SOUTHWESTERN MEDICAL CENTER · PI W MATTHEW PETROLL · 2019 to 2026
$5.9MCore Grant for Vision ResearchP30EY020799 · NEI · UT SOUTHWESTERN MEDICAL CENTER · PI NIEDERKORN, JERRY · 2010 to 2016
$4.1MExploring Mechanisms in Retinal Development/Homeostasis, Retinal Immune Surveillance and Diabetic Retinopathy Using Forward GeneticsR01EY033181 · NEI · UT SOUTHWESTERN MEDICAL CENTER · PI UFRET-VINCENTY, RAFAEL · 2021 to 2025
$2.2MRole of complement factor H and immunity in AMD: a novel transgenic modelR01EY022652 · NEI · UT SOUTHWESTERN MEDICAL CENTER · PI UFRET-VINCENTY, RAFAEL · 2012 to 2016
$2.0MTEM for UT Southwestern Electron Microscopy Core FacilityS10OD021685 · OD · UT SOUTHWESTERN MEDICAL CENTER · PI LUBY-PHELPS, KATHERINE J · 2017 to 2017
$398kNEI NIH HHS P30 EY020799NEI NIH HHS P30 EY030413NEI NIH HHS R01 EY022652NEI NIH HHS R01 EY033181NIAID NIH HHS R01 AI125581NIAID NIH HHS U19 AI100627NIH HHS S10 OD021685
Abstract
Retinal disease and loss of vision can result from any disruption of the complex pathways controlling retinal development and homeostasis. Forward genetics provides an excellent tool to find, in an unbiased manner, genes that are essential to these processes. Using
Indexed as
AnimalsCation Transport ProteinsDisease Models, AnimalDisease ProgressionElectroretinographyEthylnitrosoureaFemaleHumansMaleMiceMicroscopy, ElectronMutagenesisMutationRetinal DegenerationRetinal Photoreceptor Cell Outer SegmentRetinal Pigment EpitheliumCation Transport ProteinsEthylnitrosoureaSfxn3 protein, mouseCRISPRENU mutagenesisforward geneticsretinal degenerationSfxn3
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.