Evidence map›Paper›PMID 32457108›Full record

ArticleAntimicrobial agents and chemotherapy2020

Novel Antiparasitic Activity of the Antifungal Lead Occidiofungin.

Jingbo Ma, Fengguang Guo, Zi Jin, Mengxin Geng, Min Ju, Akshaya Ravichandran, Ravi Orugunty, Leif Smith, Guan Zhu, Haili Zhang

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Compilation of the Antimicrobial Compounds Produced byMolecules (Basel, Switzerland) · 2023
    Review
  6. Review
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jingbo MaDepartment of Veterinary Pathobiology, College of Veterinary Medicine & Biomedical Sciences, Texas A&M University, College Station, Texas, USA.
Fengguang GuoDepartment of Veterinary Pathobiology, College of Veterinary Medicine & Biomedical Sciences, Texas A&M University, College Station, Texas, USA.
Zi JinDepartment of Veterinary Pathobiology, College of Veterinary Medicine & Biomedical Sciences, Texas A&M University, College Station, Texas, USA.
Mengxin GengDepartment of Biology, College of Science, Texas A&M University, College Station, Texas, USA.
Min JuDepartment of Biology, College of Science, Texas A&M University, College Station, Texas, USA.
Akshaya RavichandranAntimicrobial Division, Sano Chemicals Inc., Bryan, Texas, USA.
Ravi OruguntyAntimicrobial Division, Sano Chemicals Inc., Bryan, Texas, USA.
Leif SmithDepartment of Biology, College of Science, Texas A&M University, College Station, Texas, USA jsmith@bio.tamu.edu gzhu@cvm.tamu.edu hzhang@cvm.tamu.edu.
Guan ZhuDepartment of Veterinary Pathobiology, College of Veterinary Medicine & Biomedical Sciences, Texas A&M University, College Station, Texas, USA jsmith@bio.tamu.edu gzhu@cvm.tamu.edu hzhang@cvm.tamu.edu.
Haili ZhangDepartment of Veterinary Pathobiology, College of Veterinary Medicine & Biomedical Sciences, Texas A&M University, College Station, Texas, USA jsmith@bio.tamu.edu gzhu@cvm.tamu.edu hzhang@cvm.tamu.edu.

Funding

Preclinical Development of OCF001 for Treatment of Yeast InfectionsR42AI131792 · NIAID · SANO CHEMICALS, INC · PI SMITH, JAMES LEIF · 2019 to 2021
$2.9M
Optimization of the Production and Isolation of the Novel Antifungal OccidiofunginR41AI122441 · NIAID · SANO CHEMICALS, INC · PI SMITH, JAMES LEIF · 2016 to 2017
$530k
Functional Characterization of the Site Specific Residues in Mutacin 1140R15AI079897 · NIAID · MISSISSIPPI STATE UNIVERSITY · PI SMITH, JAMES LEIF · 2008 to 2009
$245k
A Novel Therapeutic Agent for the Treatment of Gram-positive InfectionsR41AI149803 · NIAID · SANO CHEMICALS, INC · PI SMITH, JAMES LEIF · 2020 to 2020
$233k
Lead Compound Discovery from Engineered Analogs of OccidiofunginR41AI131792 · NIAID · SANO CHEMICALS, INC · PI SMITH, JAMES LEIF · 2017 to 2017
$225k
NIAID NIH HHS R15 AI079897NIAID NIH HHS R41 AI122441NIAID NIH HHS R41 AI131792NIAID NIH HHS R41 AI149803NIAID NIH HHS R42 AI131792
6 · The paper itself

Abstract

Novel antiparasitic activity was observed for the antifungal occidiofungin. It efficaciously and irreversibly inhibited the zoonotic enteric parasite

Indexed as

CryptosporidiosisCryptosporidiumCryptosporidium parvumAntifungal AgentsAntiparasitic AgentsGlycopeptidesHumansPeptides, CyclicAntifungal AgentsAntiparasitic AgentsGlycopeptidesoccidiofunginPeptides, CyclicCryptosporidium parvumcytotoxicityefficacyin vitrooccidiofunginprotozoan parasite

Identifiers

PMID32457108
PMCPMC7526809

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.