Evidence map›Paper›PMID 32457102›Full record

ArticleDisease models & mechanisms2020

Genetic activation of Nrf2 reduces cutaneous symptoms in a murine model of Netherton syndrome.

Sukalp Muzumdar, Michael Koch, Hayley Hiebert, Andreas Bapst, Alessia Gravina, Wilhelm Bloch, Hans-Dietmar Beer, Sabine Werner, Matthias Schäfer

Open access · goldAbstract read
In one paragraph

Article in Disease models & mechanisms, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

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  6. The Epidermis: Redox Governor of Health and Diseases.Antioxidants (Basel, Switzerland) · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Sukalp MuzumdarDepartment of Biology, Institute of Molecular Health Sciences, ETH Zurich, 8093 Zurich, Switzerland.ORCID 0000-0001-9330-4027
Michael KochDepartment of Biology, Institute of Molecular Health Sciences, ETH Zurich, 8093 Zurich, Switzerland.
Hayley HiebertDepartment of Biology, Institute of Molecular Health Sciences, ETH Zurich, 8093 Zurich, Switzerland.
Andreas BapstDepartment of Biology, Institute of Molecular Health Sciences, ETH Zurich, 8093 Zurich, Switzerland.
Alessia GravinaDepartment of Biology, Institute of Molecular Health Sciences, ETH Zurich, 8093 Zurich, Switzerland.
Wilhelm BlochDepartment of Molecular and Cellular Sport Medicine, German Sport University Cologne, 50933 Cologne, Germany.
Hans-Dietmar BeerDepartment of Dermatology, University Hospital of Zurich, Gloriastrasse 3, 8091 Zurich, Switzerland.
Sabine WernerDepartment of Biology, Institute of Molecular Health Sciences, ETH Zurich, 8093 Zurich, Switzerland sabine.werner@biol.ethz.ch matthias.schaefer@biol.ethz.ch.ORCID 0000-0001-7397-8710
Matthias SchäferDepartment of Biology, Institute of Molecular Health Sciences, ETH Zurich, 8093 Zurich, Switzerland sabine.werner@biol.ethz.ch matthias.schaefer@biol.ethz.ch.ORCID 0000-0001-6754-0448
ETH Zurich · CHGerman Sport University Cologne · DEUniversity Hospital of Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Netherton syndrome is a monogenic autosomal recessive disorder primarily characterized by the detachment of the uppermost layer of the epidermis, the

Indexed as

AnimalsCell AdhesionCell DifferentiationChemokinesDisease Models, AnimalEpidermisHumansInflammationInflammation MediatorsIntegrasesKeratinocytesMice, Inbred C57BLMice, KnockoutNAD(P)H Dehydrogenase (Quinone)Netherton SyndromeNF-E2-Related Factor 2ChemokinesCre recombinaseInflammation MediatorsIntegrasesNAD(P)H Dehydrogenase (Quinone)NF-E2-Related Factor 2NQO1 protein, humanSecretory Leukocyte Peptidase InhibitorSerine Peptidase Inhibitor Kazal-Type 5SLPI protein, humanSpink5 protein, mouseEpidermal barrierInflammationNetherton syndromeNrf2

Identifiers

PMID32457102
PMCPMC7286291
OpenAlexW3029855485

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.