Evidence map›Paper›PMID 32457089›Full record

ArticlePlant physiology2020

Plant Genome Editing and the Relevance of Off-Target Changes.

Nathaniel Graham, Gunvant B Patil, David M Bubeck, Raymond C Dobert, Kevin C Glenn, Annie T Gutsche, Sandeep Kumar, John A Lindbo, Luis Maas, Gregory D May and 3 more

Abstract read
In one paragraph

Article in Plant physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Nathaniel GrahamDepartment of Genetics, Cell Biology and Development, University of Minnesota, St. Paul, Minnesota 55108.ORCID 0000-0001-5484-4653
Gunvant B PatilDepartment of Agronomy and Plant Genetics, University of Minnesota, St. Paul, Minnesota 55108.ORCID 0000-0002-5420-9884
David M BubeckCorteva Agriscience, Johnston, Iowa 50131.
Raymond C DobertBayer Crop Science, Chesterfield, Missouri 63017.
Kevin C GlennBayer Crop Science, Chesterfield, Missouri 63017.
Annie T GutscheCorteva Agriscience, Johnston, Iowa 50131.
Sandeep KumarCorteva Agriscience, Johnston, Iowa 50131.
John A LindboHM Clause, Davis, California 95618.ORCID 0000-0002-9698-7297
Luis MaasEnza Zaden Research USA, San Juan Bautista, California 95045.
Gregory D MayCorteva Agriscience, Johnston, Iowa 50131.
Miguel E Vega-SanchezBayer Crop Science, Chesterfield, Missouri 63017.ORCID 0000-0003-0128-2743
Robert M StuparDepartment of Agronomy and Plant Genetics, University of Minnesota, St. Paul, Minnesota 55108.ORCID 0000-0002-8836-2924
Peter L MorrellDepartment of Agronomy and Plant Genetics, University of Minnesota, St. Paul, Minnesota 55108 pmorrell@umn.edu.ORCID 0000-0001-6282-1582

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Site-directed nucleases (SDNs) used for targeted genome editing are powerful new tools to introduce precise genetic changes into plants. Like traditional approaches, such as conventional crossing and induced mutagenesis, genome editing aims to improve crop yield and nutrition. Next-generation sequencing studies demonstrate that across their genomes, populations of crop species typically carry millions of single nucleotide polymorphisms and many copy number and structural variants. Spontaneous mutations occur at rates of ∼10

Indexed as

Crops, AgriculturalGene EditingGenome, PlantMutation RatePlants, Genetically Modified

Identifiers

PMID32457089
PMCPMC7401131

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.